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. 1992 Jul;60(7):2926–2935. doi: 10.1128/iai.60.7.2926-2935.1992

Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction.

R T Evans 1, B Klausen 1, H T Sojar 1, G S Bedi 1, C Sfintescu 1, N S Ramamurthy 1, L M Golub 1, R J Genco 1
PMCID: PMC257256  PMID: 1351883

Abstract

Adhesive fimbriae from Porphyromonas gingivalis are cell surface structures which may be important in the virulence of this oral pathogen and thus may serve as a critical or target antigen. Immunization with highly purified 43-kDa fimbrial protein protected against periodontal tissue destruction when tested in the P. gingivalis-infected gnotobiotic rat model. A similarly highly purified 75-kDa cell surface component did not provide protection. Heat-killed whole-cell and sonicated cell surface extracts which contain the 43-kDa protein as well as the 75-kDa component were protective also. This study indicates that the fimbrial protein may serve as a model for the development of effective vaccines against periodontitis, a major human oral disease.

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Selected References

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