Table 3.

Mean Concentrations E₂, T, or 3α-diol in the Hippocampus of Aged Intact, Young Intact, and Young GDX Male Mice 1 h Following Administration of Vehicle or 1 mg/kg s.c. E₂, T, or 3α-diol, 1 h before Testing

Condition	E2 (pg/mg)	T (ng/mg)	3α-diol (ng/mg)
Aged, intact mice
Vehicle (n = 4)	0.9 ± 0.2	0.3 ± 0.1	0.4 ± 0.1
E2 (n = 4)	6.6 ± 1.3*	0.6 ± 0.3	0.7 ± 0.1
T(n = 4)	6.7 ± 1.2*	2.6 ± 0.4*	2.0 ± 0.4*
3α-diol (n = 4)	1.3 ± 0.2	0.4 ± 0.1	3.2 ± 0.8*
Young intact mice
Vehicle (n = 5)	0.8 ± 0.4	1.0 ± 0.3	0.8 ± 0.4
E2 (n = 5)	2.0 ± 0.2#	0.6 ± 0.3	0.8 ± 0.4
T(n = 5)	0.6 ± 0.2	1.8 ± 0.4	0.6 ± 0.2
3α-diol (n = 5)	0.8 ± 0.4	1.4 ± 0.4	2.0 ± 0.6
Young, GDX mice
Vehicle (n = 5)	0.4 ± 0.3	0.4 ± 0.1	0.8 ± 0.2
E2(n = 5)	0.6 ± 0.5	0.4 ± 0.2	0.3 ± 0.2
T(n = 5)	0.7 ± 0.5	0.7 ± 0.1	1.3 ± 0.4
3α-diol(n = 5)	0.3 ± 0.2	0.4 ± 0.2	1.3 ± 0.2

^*Denotes significant difference from vehicle (P< 0.05),

^#denotes tendency to be different from control (P<0.10).