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. 1992 Aug;60(8):3105–3110. doi: 10.1128/iai.60.8.3105-3110.1992

hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae.

Y Mistry 1, D B Young 1, R Mukherjee 1
PMCID: PMC257288  PMID: 1639478

Abstract

Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy.

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