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. 1992 Oct;60(10):4407–4409. doi: 10.1128/iai.60.10.4407-4409.1992

Effects of gamma interferon and indomethacin in preventing Brucella abortus infections in mice.

M G Stevens 1, G W Pugh Jr 1, L B Tabatabai 1
PMCID: PMC257479  PMID: 1398950

Abstract

Increased resistance to infection with Brucella abortus 2308 resulted when recombinant murine gamma interferon (rMuIFN-gamma) was given to mice both before and during infection but not when given only before infection. Mice given rMuIFN-gamma had enhanced peritoneal and splenic macrophage bactericidal activity against B. abortus. Treatment of mice with rMuIFN-gamma plus indomethacin did not further enhance resistance to infection or macrophage bactericidal activity compared with that after treatment of mice with rMuIFN-gamma alone.

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Selected References

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