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. 1992 Oct;60(10):4430–4432. doi: 10.1128/iai.60.10.4430-4432.1992

Safety and immunogenicity in North Americans of a single dose of live oral cholera vaccine CVD 103-HgR: results of a randomized, placebo-controlled, double-blind crossover trial.

K L Kotloff 1, S S Wasserman 1, S O'Donnell 1, G A Losonsky 1, S J Cryz 1, M M Levine 1
PMCID: PMC257485  PMID: 1398956

Abstract

We conducted a double-blind, placebo-controlled, randomized crossover study to evaluate the safety and immunogenicity of a single 5 x 10(8)-CFU dose of live oral recombinant cholera vaccine CVD 103-HgR in 94 North American adults. The vaccine was well tolerated without associated adverse reactions. Despite minimal fecal excretion of vaccine, 97% of subjects exhibited serum vibriocidal antibody and 72% had antitoxin responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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