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. 1992 Jan;60(1):278–283. doi: 10.1128/iai.60.1.278-283.1992

Immunochemical studies and complete amino acid sequence of the streptokinase from Streptococcus pyogenes (group A) M type 12 strain A374.

H Ohkuni 1, Y Todome 1, H Suzuki 1, M Mizuse 1, N Kotani 1, K Horiuchi 1, N Shikama 1, A Tsugita 1, K H Johnston 1
PMCID: PMC257533  PMID: 1370275

Abstract

The complete amino acid sequence of the streptokinase (SKase) of Streptococcus pyogenes M type 12 strain A374, isolated from a patient with poststreptococcal glomerulonephritis (PSGN), was determined. The epitope domain for the monoclonal antibody N-59, which cross-reacts with SKases of both the PSGN-associated strain and S. equisimilis H46A (a non-PSGN-associated strain), was predicted to be localized in residues 370 to 374. The epitope domain specific for monoclonal antibody RU-1, which reacts only with the PSGN-associated SKase, was localized to residues 164 to 236.

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Selected References

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