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. 1992 Mar;60(3):1217–1220. doi: 10.1128/iai.60.3.1217-1220.1992

Chlamydia trachomatis pneumonia induces in vivo production of interleukin-1 and -6.

D M Magee 1, J G Smith 1, C A Bleicker 1, C J Carter 1, L F Bonewald 1, J Schachter 1, D M Williams 1
PMCID: PMC257615  PMID: 1541536

Abstract

Cytokine induction during Chlamydia trachomatis pneumonia may alter the pathogenesis or course of disease. We examined interleukin-1 (IL-1) and IL-6 production by measuring mRNA and bioactivity in murine lungs. mRNA and bioactivity for IL-1 alpha, IL-1 beta, and IL-6 increased after Chlamydia infection. These cytokines may be important in regulating host defenses against C. trachomatis.

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Selected References

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