Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1992 Mar;60(3):1241–1243. doi: 10.1128/iai.60.3.1241-1243.1992

Serological relationship of tumor necrosis factor-inducing exoantigens of Plasmodium falciparum and Plasmodium vivax.

C A Bate 1, J Taverne 1, N D Karunaweera 1, K N Mendis 1, D Kwiatkowski 1, J H Playfair 1
PMCID: PMC257621  PMID: 1541540

Abstract

Exoantigens of Plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. The antisera also inhibited the activity of Plasmodium falciparum and Plasmodium yoelii exoantigens, and conversely, antisera against the latter cross-reacted with the exoantigens of P. vivax.

Full text

PDF
1241

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bate C. A., Taverne J., Davé A., Playfair J. H. Malaria exoantigens induce T-independent antibody that blocks their ability to induce TNF. Immunology. 1990 Jul;70(3):315–320. [PMC free article] [PubMed] [Google Scholar]
  2. Bate C. A., Taverne J., Román E., Moreno C., Playfair J. H. Tumour necrosis factor induction by malaria exoantigens depends upon phospholipid. Immunology. 1992 Jan;75(1):129–135. [PMC free article] [PubMed] [Google Scholar]
  3. Butcher G. A., Garland T., Ajdukiewicz A. B., Clark I. A. Serum tumor necrosis factor associated with malaria in patients in the Solomon Islands. Trans R Soc Trop Med Hyg. 1990 Sep-Oct;84(5):658–661. doi: 10.1016/0035-9203(90)90134-z. [DOI] [PubMed] [Google Scholar]
  4. Clark I. A. Cell-mediated immunity in protection and pathology of malaria. Parasitol Today. 1987 Oct;3(10):300–305. doi: 10.1016/0169-4758(87)90187-6. [DOI] [PubMed] [Google Scholar]
  5. Clark I. A., Chaudhri G., Cowden W. B. Roles of tumour necrosis factor in the illness and pathology of malaria. Trans R Soc Trop Med Hyg. 1989 Jul-Aug;83(4):436–440. doi: 10.1016/0035-9203(89)90240-x. [DOI] [PubMed] [Google Scholar]
  6. Grau G. E., Taylor T. E., Molyneux M. E., Wirima J. J., Vassalli P., Hommel M., Lambert P. H. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med. 1989 Jun 15;320(24):1586–1591. doi: 10.1056/NEJM198906153202404. [DOI] [PubMed] [Google Scholar]
  7. Ihalamulla R. L., Mendis K. N. Plasmodium vivax: isolation of mature asexual stages and gametocytes from infected human blood by colloidal silica (Percoll) gradient centrifugation. Trans R Soc Trop Med Hyg. 1987;81(1):25–28. doi: 10.1016/0035-9203(87)90271-9. [DOI] [PubMed] [Google Scholar]
  8. Jeffery G. M. Epidemiological significance of repeated infections with homologous and heterologous strains and species of Plasmodium. Bull World Health Organ. 1966;35(6):873–882. [PMC free article] [PubMed] [Google Scholar]
  9. Kern P., Hemmer C. J., Van Damme J., Gruss H. J., Dietrich M. Elevated tumor necrosis factor alpha and interleukin-6 serum levels as markers for complicated Plasmodium falciparum malaria. Am J Med. 1989 Aug;87(2):139–143. doi: 10.1016/s0002-9343(89)80688-6. [DOI] [PubMed] [Google Scholar]
  10. Kwiatkowski D., Cannon J. G., Manogue K. R., Cerami A., Dinarello C. A., Greenwood B. M. Tumour necrosis factor production in Falciparum malaria and its association with schizont rupture. Clin Exp Immunol. 1989 Sep;77(3):361–366. [PMC free article] [PubMed] [Google Scholar]
  11. Kwiatkowski D., Hill A. V., Sambou I., Twumasi P., Castracane J., Manogue K. R., Cerami A., Brewster D. R., Greenwood B. M. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet. 1990 Nov 17;336(8725):1201–1204. doi: 10.1016/0140-6736(90)92827-5. [DOI] [PubMed] [Google Scholar]
  12. Mendis K. N., Naotunne T. D., Karunaweera N. D., Del Giudice G., Grau G. E., Carter R. Anti-parasite effects of cytokines in malaria. Immunol Lett. 1990 Aug;25(1-3):217–220. doi: 10.1016/0165-2478(90)90118-a. [DOI] [PubMed] [Google Scholar]
  13. Naotunne T. S., Karunaweera N. D., Del Giudice G., Kularatne M. U., Grau G. E., Carter R., Mendis K. N. Cytokines kill malaria parasites during infection crisis: extracellular complementary factors are essential. J Exp Med. 1991 Mar 1;173(3):523–529. doi: 10.1084/jem.173.3.523. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Picot S., Peyron F., Vuillez J. P., Barbe G., Marsh K., Ambroise-Thomas P. Tumor necrosis factor production by human macrophages stimulated in vitro by Plasmodium falciparum. Infect Immun. 1990 Jan;58(1):214–216. doi: 10.1128/iai.58.1.214-216.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Taverne J., Bate C. A., Kwiatkowski D., Jakobsen P. H., Playfair J. H. Two soluble antigens of Plasmodium falciparum induce tumor necrosis factor release from macrophages. Infect Immun. 1990 Sep;58(9):2923–2928. doi: 10.1128/iai.58.9.2923-2928.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Taverne J., Bate C. A., Playfair J. H. Malaria exoantigens induce TNF, are toxic and are blocked by T-independent antibody. Immunol Lett. 1990 Aug;25(1-3):207–212. doi: 10.1016/0165-2478(90)90116-8. [DOI] [PubMed] [Google Scholar]
  17. Taverne J., Bate C. A., Sarkar D. A., Meager A., Rook G. A., Playfair J. H. Human and murine macrophages produce TNF in response to soluble antigens of Plasmodium falciparum. Parasite Immunol. 1990 Jan;12(1):33–43. doi: 10.1111/j.1365-3024.1990.tb00934.x. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES