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. 1992 Mar;60(3):1244–1248. doi: 10.1128/iai.60.3.1244-1248.1992

Regional and generalized changes in cytosolic free calcium in monocytes during phagocytosis.

E Kim 1, R I Enelow 1, G W Sullivan 1, G L Mandell 1
PMCID: PMC257622  PMID: 1541541

Abstract

We measured and visualized cytosolic free calcium ([Ca2+]i) in individual human peripheral blood monocytes during phagocytosis by using the fluorescent indicator fura-2. Monocytes exhibit a rapid rise in [Ca2+]i from a basal level of 75 +/- 11 nM to a peak level of 676 +/- 78 nM (means +/- standard errors of the means; P less than 0.001) by 34 +/- 5 s after contact with opsonized zymosan particles, and a thin rim of high [Ca2+]i was observed surrounding the ingested particle.

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Selected References

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