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. 1991 Jan;59(1):421–427. doi: 10.1128/iai.59.1.421-427.1991

Interleukin-6 response to deliberate colonization of the human urinary tract with gram-negative bacteria.

S Hedges 1, P Anderson 1, G Lidin-Janson 1, P de Man 1, C Svanborg 1
PMCID: PMC257757  PMID: 1987054

Abstract

Intravesical inoculation of patients with Escherichia coli provided an opportunity to examine the interleukin-6 (IL-6) response to a gram-negative bacterial urinary tract infection in humans. All patients secreted IL-6 as a result of infection. Urinary IL-6 was not continuously secreted but appeared as a series of similar peaks during the first 48 h after infection. There was no significant difference in the ability to trigger IL-6 secretion between isogenic adhering or nonadhering strains, but a threshold concentration of 10(5) bacteria per ml of urine was necessary to fully stimulate IL-6 secretion. There was no detectable increase in IL-6 levels in the serum of the colonized individuals, suggesting mainly local IL-6 production. These results demonstrate that IL-6 is a part of the human mucosal response to gram-negative urinary tract infections.

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Selected References

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