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. 1991 Apr;59(4):1576–1578. doi: 10.1128/iai.59.4.1576-1578.1991

Effect of challenge with Candida albicans strains with different levels of virulence on plasma proteins in burned mice.

A N Neely 1, C M Childress 1, I A Holder 1
PMCID: PMC257881  PMID: 2004833

Abstract

Immunoglobulin G, immunoglobulin A, transferrin, and fibrinogen were measured by radial immunodiffusion in plasma samples from burned versus unburned mice challenged with high-virulence Candida albicans MY 1044 or its low-virulence mutant, MY 1049. Early decreases in these proteins were found after burn and/or MY 1044 but not MY 1049 challenge. These decreases may contribute to increased susceptibility of mice that were burned and challenged by MY 1044 to lethal candidiasis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Batstone G. F., Levick P. L., Spurr E., Shakespeare P. G., George S. L., Ward C. M. Changes in acute phase reactants and disturbances in metabolism after burn injury. Burns Incl Therm Inj. 1983 Mar;9(4):234–239. doi: 10.1016/0305-4179(83)90052-9. [DOI] [PubMed] [Google Scholar]
  2. Caroline L., Rosner F., Kozinn P. J. Elevated serum iron, low unbound transferrin and candidiasis in acute leukemia. Blood. 1969 Oct;34(4):441–451. [PubMed] [Google Scholar]
  3. Cline M. J., Lehrer R. I. Phagocytosis by human monocytes. Blood. 1968 Sep;32(3):423–435. [PubMed] [Google Scholar]
  4. Daniels J. C., Larson D. L., Abston S., Ritzmann S. E. Serum protein profiles in thermal burns. I. Serum electrophoretic patterns, immunoglobulins, and transport proteins. J Trauma. 1974 Feb;14(2):137–152. [PubMed] [Google Scholar]
  5. Edison A. M., Manning-Zweerink M. Comparison of the extracellular proteinase activity produced by a low-virulence mutant of Candida albicans and its wild-type parent. Infect Immun. 1988 May;56(5):1388–1390. doi: 10.1128/iai.56.5.1388-1390.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Fromtling R. A., Abruzzo G. K., Edison A., Manning-Zweerink M. Renal pathology and spleen cell chemiluminescence of mice infected with a wild-type and a low-virulence mutant of Candida albicans. Zentralbl Bakteriol Mikrobiol Hyg A. 1988 May;268(3):405–415. doi: 10.1016/s0176-6724(88)80025-7. [DOI] [PubMed] [Google Scholar]
  7. Komshian S. V., Uwaydah A. K., Sobel J. D., Crane L. R. Fungemia caused by Candida species and Torulopsis glabrata in the hospitalized patient: frequency, characteristics, and evaluation of factors influencing outcome. Rev Infect Dis. 1989 May-Jun;11(3):379–390. doi: 10.1093/clinids/11.3.379. [DOI] [PubMed] [Google Scholar]
  8. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  9. Manning M., Snoddy C. B., Fromtling R. A. Comparative pathogenicity of auxotrophic mutants of Candida albicans. Can J Microbiol. 1984 Jan;30(1):31–35. doi: 10.1139/m84-005. [DOI] [PubMed] [Google Scholar]
  10. Neely A. N., Holder I. A. Effect of proteolytic activity on virulence of Candida albicans in burned mice. Infect Immun. 1990 Jun;58(6):1527–1531. doi: 10.1128/iai.58.6.1527-1531.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pensler J. M., Herndon D. N., Ptak H., Bonds E., Rutan T. C., Desai M. H., Abston S. Fungal sepsis: an increasing problem in major thermal injuries. J Burn Care Rehabil. 1986 Nov-Dec;7(6):488–491. [PubMed] [Google Scholar]
  12. Risberg B., Medegård A., Heideman M., Gyzander E., Bundsen P., Odén M., Teger-Nilsson A. C. Early activation of humoral proteolytic systems in patients with multiple trauma. Crit Care Med. 1986 Nov;14(11):917–925. doi: 10.1097/00003246-198611000-00001. [DOI] [PubMed] [Google Scholar]
  13. Rund T. E., Kierulf P., Godal H. C., Aune S., Aasen A. O. Studies on pathological plasma proteolysis in severely burned patients using chromogenic peptide substrate assays: a preliminary report. Adv Exp Med Biol. 1984;167:449–454. doi: 10.1007/978-1-4615-9355-3_39. [DOI] [PubMed] [Google Scholar]
  14. Solomkin J. S., Mills E. L., Giebink G. S., Nelson R. D., Simmons R. L., Quie P. G. Phagocytosis of Candida albicans by human leukocytes: opsonic requirements. J Infect Dis. 1978 Jan;137(1):30–37. doi: 10.1093/infdis/137.1.30. [DOI] [PubMed] [Google Scholar]
  15. Stein D. K., Sugar A. M. Fungal infections in the immunocompromised host. Diagn Microbiol Infect Dis. 1989 Jul-Aug;12(4 Suppl):221S–228S. doi: 10.1016/0732-8893(89)90140-5. [DOI] [PubMed] [Google Scholar]
  16. Valenti P., Visca P., Antonini G., Orsi N. Antifungal activity of ovotransferrin towards genus Candida. Mycopathologia. 1985 Mar;89(3):169–175. doi: 10.1007/BF00447027. [DOI] [PubMed] [Google Scholar]

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