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. 1991 May;59(5):1762–1771. doi: 10.1128/iai.59.5.1762-1771.1991

Chromosomal rearrangement in Candida stellatoidea results in a positive effect on phenotype.

B L Wickes 1, J E Golin 1, K J Kwon-Chung 1
PMCID: PMC257913  PMID: 2019440

Abstract

When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 10(8) cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements have been studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement.

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Selected References

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