Abstract
We are performing a randomized, controlled trial of a Physician's Workstation (PWS), an ambulatory care information system, developed for use in the General Medical Clinic (GMC) of the Palo Alto VA. Goals for the project include selecting appropriate outcome variables and developing a statistically powerful experimental design with a limited number of subjects. As PWS provides real-time drug-ordering advice, we retrospectively examined drug costs and drug-drug interactions in order to select outcome variables sensitive to our short-term intervention as well as to estimate the statistical efficiency of alternative design possibilities. Drug cost data revealed the mean daily cost per physician per patient was 99.3 cents +/- 13.4 cents, with a range from 0.77 cent to 1.37 cents. The rate of major interactions per prescription for each physician was 2.9% +/- 1%, with a range from 1.5% to 4.8%. Based on these baseline analyses, we selected a two-period parallel design for the evaluation, which maximized statistical power while minimizing sources of bias.
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Selected References
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- Britton M. L., Lurvey P. L. Impact of medication profile review on prescribing in a general medicine clinic. Am J Hosp Pharm. 1991 Feb;48(2):265–270. [PubMed] [Google Scholar]
- Brown B. W., Jr The crossover experiment for clinical trials. Biometrics. 1980 Mar;36(1):69–79. [PubMed] [Google Scholar]
- Chassan J. B. A note on relative efficiency in clinical trials. J Clin Pharmacol J New Drugs. 1970 Sep-Oct;10(5):359–360. doi: 10.1177/009127007001000511. [DOI] [PubMed] [Google Scholar]
- Covell D. G., Uman G. C., Manning P. R. Information needs in office practice: are they being met? Ann Intern Med. 1985 Oct;103(4):596–599. doi: 10.7326/0003-4819-103-4-596. [DOI] [PubMed] [Google Scholar]
- Donald J. B. Prescribing costs when computers are used to issue all prescriptions. BMJ. 1989 Jul 1;299(6690):28–30. doi: 10.1136/bmj.299.6690.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hershey C. O., Porter D. K., Breslau D., Cohen D. I. Influence of simple computerized feedback on prescription charges in an ambulatory clinic. A randomized clinical trial. Med Care. 1986 Jun;24(6):472–481. doi: 10.1097/00005650-198606000-00002. [DOI] [PubMed] [Google Scholar]
- Jankel C. A., Speedie S. M. Detecting drug interactions: a review of the literature. DICP. 1990 Oct;24(10):982–989. doi: 10.1177/106002809002401014. [DOI] [PubMed] [Google Scholar]
- Kramer M. S., Shapiro S. H. Scientific challenges in the application of randomized trials. JAMA. 1984 Nov 16;252(19):2739–2745. [PubMed] [Google Scholar]
- McDonald C. J., Hui S. L., Smith D. M., Tierney W. M., Cohen S. J., Weinberger M., McCabe G. P. Reminders to physicians from an introspective computer medical record. A two-year randomized trial. Ann Intern Med. 1984 Jan;100(1):130–138. doi: 10.7326/0003-4819-100-1-130. [DOI] [PubMed] [Google Scholar]
- McDonald C. J., Tierney W. M. Computer-stored medical records. Their future role in medical practice. JAMA. 1988 Jun 17;259(23):3433–3440. [PubMed] [Google Scholar]
- McPhee S. J., Bird J. A., Fordham D., Rodnick J. E., Osborn E. H. Promoting cancer prevention activities by primary care physicians. Results of a randomized, controlled trial. JAMA. 1991 Jul 24;266(4):538–544. [PubMed] [Google Scholar]
- Tang P. C., Annevelink J., Fafchamps D., Stanton W. M., Young C. Y. Physicians' workstations: integrated information management for clinicians. Proc Annu Symp Comput Appl Med Care. 1991:569–573. [PMC free article] [PubMed] [Google Scholar]
- Tang P. C., Annevelink J., Suermondt H. J., Young C. Y. Semantic integration of information in a physician's workstation. Int J Biomed Comput. 1994 Feb;35(1):47–60. doi: 10.1016/0020-7101(94)90048-5. [DOI] [PubMed] [Google Scholar]
- Tierney W. M., Miller M. E., Overhage J. M., McDonald C. J. Physician inpatient order writing on microcomputer workstations. Effects on resource utilization. JAMA. 1993 Jan 20;269(3):379–383. [PubMed] [Google Scholar]
- Tierney W. M., Overhage J. M., McDonald C. J. A plea for controlled trials in medical informatics. J Am Med Inform Assoc. 1994 Jul-Aug;1(4):353–355. doi: 10.1136/jamia.1994.95236170. [DOI] [PMC free article] [PubMed] [Google Scholar]
