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. 1991 Jun;59(6):2192–2194. doi: 10.1128/iai.59.6.2192-2194.1991

Differential effects of monophosphoryl lipid A on expression of suppressor T cell activity in lipopolysaccharide-responsive and lipopolysaccharide-defective strains of C3H mice.

F S Ekwunife 1, C E Taylor 1, M B Fauntleroy 1, P W Stashak 1, P J Baker 1
PMCID: PMC257987  PMID: 1828058

Abstract

Lipopolysaccharide (LPS)-responsive and LPS-defective strains of C3H mice did not differ in the capacity to make an antibody response to type III pneumococcal polysaccharide or in the degree of thymus-derived suppressor cell (Ts) activity generated following exposure to type III pneumococcal polysaccharide. However, treatment with monophosphoryl lipid A (MPL) abolished the expression of Ts function in LPS-responsive but not LPS-defective mice. Since this effect was elicited by different preparations of MPL, it appears to be a general property of MPL mediated by direct action of MPL on activated Ts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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