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. 1991 Jul;59(7):2499–2501. doi: 10.1128/iai.59.7.2499-2501.1991

Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes.

R W Harris 1, P J Sims 1, R K Tweten 1
PMCID: PMC258038  PMID: 2050414

Abstract

Clostridium perfringens theta-toxin was shown to lyse target erythrocytes by a colloid-osmotic mechanism. Analysis showed the onset of lysis of erythrocytes by theta-toxin could be temporarily stabilized with 0.3 M sucrose. Flow cytometry analysis of the size distribution of theta-toxin-treated erythrocytes showed swelling of the erythrocytes prior to lysis.

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Selected References

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