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. 1991 Aug;59(8):2846–2850. doi: 10.1128/iai.59.8.2846-2850.1991

Stimulation of proteinase and amidase activities in Porphyromonas (Bacteroides) gingivalis by amino acids and dipeptides.

Z X Chen 1, J Potempa 1, A Polanowski 1, S Renvert 1, M Wikström 1, J Travis 1
PMCID: PMC258097  PMID: 1855999

Abstract

Proteolytic enzymes from the organism Porphyromonas gingivalis are believed to be involved in the development of periodontitis. Studies on both crude extracts and purified trypsinlike enzymes from this organism indicate that substantial stimulation of both amidase and proteinase activities can be obtained during incubation with glycine-containing compounds. We postulate that P. gingivalis may have developed this unusual property to take advantage of the glycine-rich environment which occurs during the periodontitis-associated degradation of gingival collagen. The finding of such a stimulation in crevicular fluids from discrete periodontal sites has been correlated with the presence of P. gingivalis and could be utilized for the early detection of infection by this organism during the onset of periodontitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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