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. 1992 Nov;60(11):4953–4956. doi: 10.1128/iai.60.11.4953-4956.1992

Novel adjuvant action of lipopolysaccharides that possess mannose homopolysaccharides as O-specific polysaccharides on immune responses to nonimmunogenic autoantigens in mice.

T Yokochi 1, M Fukada 1, M Kawai 1, Y H Zhang 1, G Z Jiang 1, K Takahashi 1
PMCID: PMC258254  PMID: 1383160

Abstract

The adjuvant action of various lipopolysaccharides on immune responses to syngeneic tissue extract in mice was examined. Only lipopolysaccharides possessing the linear mannose homopolysaccharides as O-specific polysaccharides exhibited definite adjuvant action on immune responses to the autoantigens. The intensity of this adjuvant activity of lipopolysaccharide from Klebsiella O3 seemed to be the strongest.

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Selected References

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  1. CLAMAN H. N. TOLERANCE TO A PROTEIN ANTIGEN IN ADULT MICE AND THE EFFECT OF NONSPECIFIC FACTORS. J Immunol. 1963 Dec;91:833–839. [PubMed] [Google Scholar]
  2. Capanna S. L., Kong Y. M. Further studies on the prevention of tolerance induction by poly A:U. Immunology. 1974 Oct;27(4):647–653. [PMC free article] [PubMed] [Google Scholar]
  3. Curvall M., Lindberg B., Lönngren J., Nimmich W. Structural studies on the Klebsiella O group 3 lipopolysaccharide. Acta Chem Scand. 1973;27(7):2645–2649. doi: 10.3891/acta.chem.scand.27-2645. [DOI] [PubMed] [Google Scholar]
  4. Ezekowitz R. A., Sim R. B., Hill M., Gordon S. Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan. J Exp Med. 1984 Jan 1;159(1):244–260. doi: 10.1084/jem.159.1.244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fukazawa Y., Kagaya K., Miura H. Biological and biochemical characterization of macrophage activating factor (MAF) in murine lymphocytes: role of mannopyranosyl residue of the MAF molecule in macrophage activation. Microbiol Immunol. 1981;25(11):1163–1172. doi: 10.1111/j.1348-0421.1981.tb00124.x. [DOI] [PubMed] [Google Scholar]
  6. Golub E. S., Weigle W. O. Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol. 1967 Jun;98(6):1241–1247. [PubMed] [Google Scholar]
  7. Jansson P. E., Lönngren J., Widmalm G., Leontein K., Slettengren K., Svenson S. B., Wrangsell G., Dell A., Tiller P. R. Structural studies of the O-antigen polysaccharides of Klebsiella O5 and Escherichia coli O8. Carbohydr Res. 1985 Dec 15;145(1):59–66. doi: 10.1016/s0008-6215(00)90412-9. [DOI] [PubMed] [Google Scholar]
  8. Kato N., Ohta M., Kido N., Naito S., Nakashima I., Nagase F., Yokochi T. Strong adjuvanticity of bacterial lipopolysaccharides possessing the homopolysaccharides consisting of mannose as the O-specific polysaccharide chains. Med Microbiol Immunol. 1985;174(1):1–14. [PubMed] [Google Scholar]
  9. Katsura Y. Studies on M and G antibody response of mice to bovine serum albumin. I. A systematic survey of immunizing conditions. Jpn J Microbiol. 1972 May;16(3):223–232. doi: 10.1111/j.1348-0421.1972.tb00652.x. [DOI] [PubMed] [Google Scholar]
  10. Kido N., Ohta M., Ito H., Naito S., Nagase F., Nakashima I., Kato N. Potent adjuvant action of lipopolysaccharides possessing the O-specific polysaccharide moieties consisting of mannans in antibody response against protein antigen. Cell Immunol. 1985 Mar;91(1):52–59. doi: 10.1016/0008-8749(85)90031-0. [DOI] [PubMed] [Google Scholar]
  11. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  12. Nilsson B. S., Sultzer B. M., Bullock W. W. Purified protein derivative of tuberculin induces immunoglobulin production in normal mouse spleen cells. J Exp Med. 1973 Jan 1;137(1):127–139. doi: 10.1084/jem.137.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Ohta M., Mori M., Hasegawa T., Nagase F., Nakashima I., Naito S., Kato N. Further Studies of the polysaccharide of Klebsiella pneumoniae possessing strong adjuvanticity. I. Production of the adjuvant polysaccharide by noncapsulated mutant. Microbiol Immunol. 1981;25(9):939–948. doi: 10.1111/j.1348-0421.1981.tb00098.x. [DOI] [PubMed] [Google Scholar]
  14. Ohta M., Okada M., Yamashina I., Kawasaki T. The mechanism of carbohydrate-mediated complement activation by the serum mannan-binding protein. J Biol Chem. 1990 Feb 5;265(4):1980–1984. [PubMed] [Google Scholar]
  15. Ornellas E. P., Sanfilippo F., Scott D. W. Cellular events in tolerance. IV. The effect of a graft-versus-host reaction and endotoxin on hapten- and carrier-specific tolerance. Eur J Immunol. 1974 Sep;4(9):587–591. doi: 10.1002/eji.1830040902. [DOI] [PubMed] [Google Scholar]
  16. Prehm P., Jann B., Jann K. The O9 antigen of Escherichia coli. Structure of the polysaccharide chain. Eur J Biochem. 1976 Aug 1;67(1):53–56. doi: 10.1111/j.1432-1033.1976.tb10631.x. [DOI] [PubMed] [Google Scholar]
  17. Yokochi T., Ikeda H., Inoue Y., Kimura Y., Ito H., Fujii Y., Kato N. Characterization of autoantigens relevant to experimental autoimmune orchitis (EAO) in mice immunized with a mixture of syngeneic testis homogenate and Klebsiella O3 lipopolysaccharide. Am J Reprod Immunol. 1990 Jan-Feb;22(1-2):42–48. doi: 10.1111/j.1600-0897.1990.tb01030.x. [DOI] [PubMed] [Google Scholar]
  18. Yokochi T., Inoue Y., Kimura Y., Kato N. Strong interaction of lipopolysaccharides possessing the mannose homopolysaccharides with complement and its relation to adjuvant action. J Immunol. 1990 Apr 15;144(8):3106–3110. [PubMed] [Google Scholar]
  19. Yokochi T., Inoue Y., Miyadai T., Kimura Y., Ito H., Kato N. A possible correlation between histological changes in regional subcutaneous tissue induced by bacterial lipopolysaccharides and their adjuvant activities. Microbiol Immunol. 1989;33(9):747–760. doi: 10.1111/j.1348-0421.1989.tb00961.x. [DOI] [PubMed] [Google Scholar]
  20. Yokochi T., Inoue Y., Yokoo J., Kimura Y., Kato N. Retention of bacterial lipopolysaccharide at the site of subcutaneous injection. Infect Immun. 1989 Jun;57(6):1786–1791. doi: 10.1128/iai.57.6.1786-1791.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Yokochi T., Nakashima I., Kato N., Asai J. Microbial adjuvant and autoimmunity. III. Histological studies of development of experimental autoimmune thyroiditis in mice immunized with syngeneic thyroid extract together with the capsular polysaccharide of Klebsiella pneumoniae. Microbiol Immunol. 1978;22(10):619–630. doi: 10.1111/j.1348-0421.1978.tb00412.x. [DOI] [PubMed] [Google Scholar]

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