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. 1992 Dec;60(12):5316–5318. doi: 10.1128/iai.60.12.5316-5318.1992

A bactericidal monoclonal antibody specific for the lipooligosaccharide of Bordetella pertussis reduces colonization of the respiratory tract of mice after aerosol infection with B. pertussis.

K T Mountzouros 1, A Kimura 1, J L Cowell 1
PMCID: PMC258314  PMID: 1452367

Abstract

A mouse immunoglobulin G3 monoclonal antibody specific for the core oligosaccharide moiety of the lipooligosaccharide (LOS) of Bordetella pertussis has been shown to have complement-dependent bactericidal activity. This monoclonal antibody exhibits bactericidal activity against strains of B. pertussis that express the LOS A phenotype. In addition this monoclonal antibody was effective in reducing colonization by B. pertussis in both the lungs and tracheas of mice after aerosol infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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