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In silico mapping of INA incorporation into gp41. gp41 was labeled with INA and purified to homogeneity. Upon digestion with V8 and trypsin, the peptides generated were analyzed by MALDI analysis (representative spectra shown). The observed peptides were compared to the theoretical computed ones. Differences corresponding to the possible incorporation of INA molecules within 25 ppm were conserved. (A) gp41 recovered before fusion. (B) gp41 recovered after fusion.
