. Author manuscript; available in PMC: 2008 Dec 1.

Published in final edited form as: Neuropsychopharmacology. 2008 Aug 13;33(13):3078–3084. doi: 10.1038/npp.2008.126

Table 1.

Variation in the COMT gene

SNP	Sample	n	Genotype frequency			P^*^a	Allele frequency	P^*^b
rs737865			A/A	A/G	G/G		f(A)
	Cocaine	330	0.715	0.255	0.030	0.312	0.842	0.766
	Controls	253	0.688	0.296	0.016		0.836
Val158Met^c			Val/Val	Val/Met	Met/Met		f(Met)
	Cocaine	324	0.417	0.469	0.114	0.011	0.349	0.004^d
	Controls	255	0.541	0.376	0.082		0.271
rs165599			A/A	A/G	G/G		f(x)
	Cocaine	324	0.454	0.441	0.105	0.258	0.674	0.196
	Controls	255	0.486	0.447	0.067		0.710

^*ab

type-I error rates for comparison of genotype and allele frequencies between BPD patients and controls.

Val158Met=rs4680=rs165688 (Val=G)

Global significance after permutation correction for multiple testing: p=0.014 Standard Error (SE): 0.001175