Table 1.
Examples of cancer therapies and severe neurotoxic outcomes
| AGENT | DIAGNOSIS | NEUROTOXICITY EXAMPLES |
|---|---|---|
| l-asparaginase | Lymphocytic anemia | Depression, confusion |
| Busulfan | Bone marrow transplant | Seizures (children) |
| Cisplatin (intra-arterial) | Brain tumor | Peripheral neuropathy |
| Ifosfamide | Solid tumors (children) | Confusion, irritability |
| Interleukin-2 | Renal cancer | Disorientation, confusion |
| Nitrogen mustards | Bone marrow transplant | Hallucinations, tremor |
| Methotrexate | Child leukemia | Personality changes |
| Paclitaxel (taxol) | Breast cancer | Confusion, neuropathy |
| Carmustine (BCNU) | Gliomas | Leukoencephalopathy |
| Vincristine | Hodgkin’s disease | Peripheral neuropathy |
| Cranial irradiation (children) | Acute lymphoblastic leukemia (ALL) | Somnolence, advanced cognitive impairment |