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. 1991 Mar;59(3):1170–1171. doi: 10.1128/iai.59.3.1170-1171.1991

Virulence of ureaplasmal urease for mice.

J V Ligon 1, G E Kenny 1
PMCID: PMC258383  PMID: 1997418

Abstract

Ureaplasmas killed mice within 5 min after intravenous injection. The 50% lethal dose of whole ureaplasmal organisms was 32 micrograms per mouse, a value also found for crystalline jackbean urease. The reaction was specific to urease, since protection was afforded by intraperitoneal injection of 200 micrograms of flurofamide, a potent urease inhibitor. The finding that a similar lethal effect was produced by injection of 200 mumol of NH4+ indicates that the toxicity of urease is mediated by ammonium ions or free ammonia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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