Abstract
A blood stage-induced P. brasilianum infection in a naive squirrel monkey induced antibodies which reacted with the circumsporozoite protein of the parasite. Titers increased with duration of infection and persisted for 3 months after cure. In an immunoblot, these antibodies detected two polypeptides with molecular weights identical to those of the circumsporozoite protein and its precursor.
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- Cochrane A. H., Ockenhouse C. F., Nussenzweig R. S. Identification of circumsporozoite proteins in individual malaria-infected mosquitoes by western blot analysis. J Immunol Methods. 1984 Jul 6;71(2):241–245. doi: 10.1016/0022-1759(84)90070-x. [DOI] [PubMed] [Google Scholar]
- Cochrane A. H., Uni S., Maracic M., Di Giovanni L., Aikawa M., Nussenzweig R. S. A circumsporozoite-like protein is present in micronemes of mature blood stages of malaria parasites. Exp Parasitol. 1989 Nov;69(4):351–356. doi: 10.1016/0014-4894(89)90084-2. [DOI] [PubMed] [Google Scholar]
- Coppel R. L., Favaloro J. M., Crewther P. E., Burkot T. R., Bianco A. E., Stahl H. D., Kemp D. J., Anders R. F., Brown G. V. A blood stage antigen of Plasmodium falciparum shares determinants with the sporozoite coat protein. Proc Natl Acad Sci U S A. 1985 Aug;82(15):5121–5125. doi: 10.1073/pnas.82.15.5121. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Daniel-Ribeiro C., de Oliveira-Ferreira J., Banic D. M., Galvão-Castro B. Can malaria-associated polyclonal B-lymphocyte activation interfere with the development of anti-sporozoite specific immunity? Trans R Soc Trop Med Hyg. 1989 May-Jun;83(3):289–292. doi: 10.1016/0035-9203(89)90476-8. [DOI] [PubMed] [Google Scholar]
- Hope I. A., Hall R., Simmons D. L., Hyde J. E., Scaife J. G. Evidence for immunological cross-reaction between sporozoites and blood stages of a human malaria parasite. Nature. 1984 Mar 8;308(5955):191–194. doi: 10.1038/308191a0. [DOI] [PubMed] [Google Scholar]
- Nardin E. H., Nussenzweig R. S., McGregor I. A., Bryan J. H. Antibodies to sporozoites: their frequent occurrence in individuals living in an area of hyperendemic malaria. Science. 1979 Nov 2;206(4418):597–599. doi: 10.1126/science.386511. [DOI] [PubMed] [Google Scholar]
- Nussenzweig V., Nussenzweig R. S. Rationale for the development of an engineered sporozoite malaria vaccine. Adv Immunol. 1989;45:283–334. doi: 10.1016/s0065-2776(08)60695-1. [DOI] [PubMed] [Google Scholar]
- Orjih A. U., Nussenzweig R. S. Plasmodium berghei: suppression of antibody response to sporozoite stage by acute blood stage infection. Clin Exp Immunol. 1979 Oct;38(1):1–8. [PMC free article] [PubMed] [Google Scholar]
- Tapchaisri P., Chomcharn Y., Poonthong C., Asavanich A., Limsuwan S., Maleevan O., Tharavanij S., Harinasuta T. Anti-sporozoite antibodies induced by natural infection. Am J Trop Med Hyg. 1983 Nov;32(6):1203–1208. doi: 10.4269/ajtmh.1983.32.1203. [DOI] [PubMed] [Google Scholar]
- Vanderberg J., Nussenzweig R., Most H. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. V. In vitro effects of immune serum on sporozoites. Mil Med. 1969 Sep;134(10):1183–1190. [PubMed] [Google Scholar]
- Zavala F., Tam J. P., Masuda A. Synthetic peptides as antigens for the detection of humoral immunity to Plasmodium falciparum sporozoites. J Immunol Methods. 1986 Oct 23;93(1):55–61. doi: 10.1016/0022-1759(86)90432-1. [DOI] [PubMed] [Google Scholar]