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. 1991 Mar;59(3):1188–1191. doi: 10.1128/iai.59.3.1188-1191.1991

An interleukin-1 receptor antagonist blocks lipopolysaccharide-induced colony-stimulating factor production and early endotoxin tolerance.

B E Henricson 1, R Neta 1, S N Vogel 1
PMCID: PMC258388  PMID: 1825485

Abstract

In this report, administration of a recombinant interleukin-1 receptor antagonist protein to mice was found to inhibit induction of colony-stimulating factor as well as induction of early endotoxin tolerance by lipopolysaccharide. These findings provide direct evidence that interleukin-1 is an intermediate in these two lipopolysaccharide-induced phenomena.

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Selected References

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