Abstract
Passively transferred immune serum provided significantly greater protection to BALB/c mice against attenuated Brucella abortus 19 than against virulent strain 2308, whether serum donors had been infected with strain 19 or 2308. In contrast, immune T cells conferred better protection upon recipients challenged with the homologous strain of B. abortus. It is hypothesized that strain 2308, but not strain 19, can survive in macrophages after opsonization and that epitopes which induce protective cell-mediated immunity may differ between strains 19 and 2308.
Full text
PDF![254](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/258438/567071956a2b/iai00049-0270.png)
![255](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/258438/c402b6a2a830/iai00049-0271.png)
![256](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/258438/b39f2c30d60d/iai00049-0272.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bascoul S., Cannat A., Huguet M. F., Serre A. Studies on the immune protection to murine experimental brucellosis conferred by Brucella fractions. I. Positive role of immune serum. Immunology. 1978 Aug;35(2):213–221. [PMC free article] [PubMed] [Google Scholar]
- Cheers C., Pagram F. Macrophage activation during experimental murine brucellosis: a basis for chronic infection. Infect Immun. 1979 Feb;23(2):197–205. doi: 10.1128/iai.23.2.197-205.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheers C. Pathogenesis and cellular immunity in experimental murine brucellosis. Dev Biol Stand. 1984;56:237–246. [PubMed] [Google Scholar]
- Frenchick P. J., Markham R. J., Cochrane A. H. Inhibition of phagosome-lysosome fusion in macrophages by soluble extracts of virulent Brucella abortus. Am J Vet Res. 1985 Feb;46(2):332–335. [PubMed] [Google Scholar]
- Limet J., Plommet A. M., Dubray G., Plommet M. Immunity conferred upon mice by anti-LPS monoclonal antibodies in murine brucellosis. Ann Inst Pasteur Immunol. 1987 May-Jun;138(3):417–424. doi: 10.1016/s0769-2625(87)80052-1. [DOI] [PubMed] [Google Scholar]
- MACKANESS G. B. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med. 1964 Jul 1;120:105–120. doi: 10.1084/jem.120.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Madraso E. D., Cheers C. Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis. Immunology. 1978 Jul;35(1):77–84. [PMC free article] [PubMed] [Google Scholar]
- Montaraz J. A., Winter A. J. Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice. Infect Immun. 1986 Aug;53(2):245–251. doi: 10.1128/iai.53.2.245-251.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Montaraz J. A., Winter A. J., Hunter D. M., Sowa B. A., Wu A. M., Adams L. G. Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies. Infect Immun. 1986 Mar;51(3):961–963. doi: 10.1128/iai.51.3.961-963.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pardon P. Resistance against a subcutaneous Brucella challenge of mice immunized with living or dead Brucella or by transfer of immune serum. Ann Immunol (Paris) 1977 Nov-Dec;128(6):1025–1037. [PubMed] [Google Scholar]
- Pavlov H., Hogarth M., McKenzie I. F., Cheers C. In vivo and in vitro effects of monoclonal antibody to Ly antigens on immunity to infection. Cell Immunol. 1982 Jul 15;71(1):127–138. doi: 10.1016/0008-8749(82)90502-0. [DOI] [PubMed] [Google Scholar]
- Plommet M., Plommet A. M. Immune serum-mediated effects on brucellosis evolution in mice. Infect Immun. 1983 Jul;41(1):97–105. doi: 10.1128/iai.41.1.97-105.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SULITZEANU D. Passive protection experiments with Brucella antisera. J Hyg (Lond) 1955 Jun;53(2):133–142. doi: 10.1017/s0022172400000619. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Winter A. J., Rowe G. E., Duncan J. R., Eis M. J., Widom J., Ganem B., Morein B. Effectiveness of natural and synthetic complexes of porin and O polysaccharide as vaccines against Brucella abortus in mice. Infect Immun. 1988 Nov;56(11):2808–2817. doi: 10.1128/iai.56.11.2808-2817.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wysocki L. J., Sato V. L. "Panning" for lymphocytes: a method for cell selection. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2844–2848. doi: 10.1073/pnas.75.6.2844. [DOI] [PMC free article] [PubMed] [Google Scholar]