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. 1990 Jan;58(1):260–262. doi: 10.1128/iai.58.1.260-262.1990

Prostaglandin E2 enhances and gamma interferon inhibits germ tube formation in Candida albicans.

A Kalo-Klein 1, S S Witkin 1
PMCID: PMC258440  PMID: 2152888

Abstract

Prostaglandin E2 (PGE2), an immunosuppressive monokine that increases intracellular cyclic AMP (cAMP) levels, stimulated Candida albicans germ tube formation. Dibutyryl cAMP (dB-cAMP) and isoproterenol, other compounds that increase cAMP levels, also stimulated germination. Gamma interferon (IFN-gamma), a product of cellular immune system activation, inhibited Candida germ tube formation, even in the presence of PGE2, dB-cAMP, and isoproterenol. Thus, PGE2 and IFN-gamma as well as having opposing roles in the suppression or activation of cell-mediated immunity, are also antagonists for the yeast-to-hyphal transition of C. albicans.

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Selected References

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