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. 1990 Jan;58(1):269–271. doi: 10.1128/iai.58.1.269-271.1990

Stimulation of antibacterial macrophage activities by B-cell stimulatory factor 2 (interleukin-6).

I E Flesch 1, S H Kaufmann 1
PMCID: PMC258443  PMID: 2104600

Abstract

Mononuclear phagocytes provide the major habitat of intracellular bacteria, including Mycobacterium tuberculosis and Mycobacterium bovis. The capacity of B-cell stimulatory factor 2 (interleukin-6 [IL-6]) to activate tuberculostatic functions was investigated by using murine bone marrow-derived macrophages (BMM phi). BMM phi stimulated with recombinant IL-6 and subsequently infected with M. bovis organisms failed to inhibit mycobacterial growth. In contrast, marked tuberculostasis was induced by IL-6 in BMM phi that were already infected with M. bovis, indicating that IL-6 has a macrophage-activating function.

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Selected References

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