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. 1990 Feb;58(2):557–562. doi: 10.1128/iai.58.2.557-562.1990

Passive immunization of chickens against Eimeria maxima infection with a monoclonal antibody developed against a gametocyte antigen.

M Wallach 1, G Pillemer 1, S Yarus 1, A Halabi 1, T Pugatsch 1, D Mencher 1
PMCID: PMC258493  PMID: 2298492

Abstract

Eimeria maxima gametocytes contain two major antigens with molecular masses of 56 and 82 kilodaltons (kDa) which are recognized by convalescent sera from immune chickens. Preparations enriched in these two antigens were used to immunize mice, and several monoclonal antibodies which specifically reacted with the 56-kDa antigen were produced. One of these monoclonal antibodies of the immunoglobulin M subclass, along with immune chicken sera raised against affinity-purified 56- and 82-kDa antigens, was used to passively immunize chicks. On the basis of the parameter of total oocyst output, it was found that these antibodies provided partial protection (40 to 50% inhibition) against E. maxima challenge infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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