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. 1990 Feb;58(2):575–578. doi: 10.1128/iai.58.2.575-578.1990

Identification of a T-cell epitope on the circumsporozoite protein of Plasmodium vivax.

F W George 4th 1, J L Law 1, K A Rich 1, W J Martin 1
PMCID: PMC258498  PMID: 1688828

Abstract

A series of overlapping peptides, representing sequences in the vicinity of region II on the Plasmodium vivax circumsporozoite protein, was synthesized. One of the peptides (PV-23), a 20-mer containing the 6 C-terminal amino acids of region II, was found to evoke an in vitro T-cell proliferative response in spleen cells from C3Hf (H-2km2) mice immunized with the peptide. These results demonstrate that PV-23 contains a T-cell epitope. To our knowledge, this is the first report of a T-cell epitope on the circumsporozoite protein of P. vivax.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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