Table 3. Summary of effects of inhibitors of α-ketoglutarate hydroxylases on enzyme activity in the presence of endogenous substrates in INS-1 cell cytosol.
Results are typical of six separate experiments
| Incubation Condition | Relative enzyme activity(Expressed as a % of control = 100%) |
| Cytosol | 100% |
| No cytosol | 10–18% |
| Cytosol, heated | 5% |
| Cytosol + 60 mM ZnCl2 | 15–34% |
| Cytosol + 5 mM 2-methyl-α-ketoglutarate | 25% |
| Cytosol + 5 mM 3-methyl-α-ketoglutarate | 48% |
| Cytosol + 2.5 mM ethyl-3,4-dihydroxybenzoate | 49% |