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. 1990 Mar;58(3):833–834. doi: 10.1128/iai.58.3.833-834.1990

Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts.

J D Schwartzman 1, S L Gonias 1, E R Pfefferkorn 1
PMCID: PMC258541  PMID: 2106497

Abstract

Although treatment of human macrophages or fibroblasts with human gamma interferon results in the inhibition of intracellular Toxoplasma gondii, murine gamma interferon stimulated only murine macrophages, not murine fibroblasts, to inhibit T. gondii. This species difference may be important in understanding the control of acute and chronic toxoplasmosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Araujo F. G., Williams D. M., Grumet F. C., Remington J. S. Strain-dependent differences in murine susceptibility to toxoplasma. Infect Immun. 1976 May;13(5):1528–1530. doi: 10.1128/iai.13.5.1528-1530.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Chinchilla M., Frenkel J. K. Specific mediation of cellular immunity to Toxoplasma gondii in somatic cells of mice. Infect Immun. 1984 Dec;46(3):862–866. doi: 10.1128/iai.46.3.862-866.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gonias S. L., Young W. W., Jr, Fox J. W. Cleavage of recombinant murine interferon-gamma by plasmin and miniplasmin. J Interferon Res. 1989 Oct;9(5):517–529. doi: 10.1089/jir.1989.9.517. [DOI] [PubMed] [Google Scholar]
  4. Murray H. W., Szuro-Sudol A., Wellner D., Oca M. J., Granger A. M., Libby D. M., Rothermel C. D., Rubin B. Y. Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages. Infect Immun. 1989 Mar;57(3):845–849. doi: 10.1128/iai.57.3.845-849.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med. 1983 Sep 1;158(3):670–689. doi: 10.1084/jem.158.3.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Pestka S., Langer J. A., Zoon K. C., Samuel C. E. Interferons and their actions. Annu Rev Biochem. 1987;56:727–777. doi: 10.1146/annurev.bi.56.070187.003455. [DOI] [PubMed] [Google Scholar]
  7. Pfefferkorn E. R., Eckel M., Rebhun S. Interferon-gamma suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan. Mol Biochem Parasitol. 1986 Sep;20(3):215–224. doi: 10.1016/0166-6851(86)90101-5. [DOI] [PubMed] [Google Scholar]
  8. Pfefferkorn E. R., Guyre P. M. Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon. Infect Immun. 1984 May;44(2):211–216. doi: 10.1128/iai.44.2.211-216.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Pfefferkorn E. R. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci U S A. 1984 Feb;81(3):908–912. doi: 10.1073/pnas.81.3.908. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pfefferkorn E. R., Pfefferkorn L. C. Toxoplasma gondii: isolation and preliminary characterization of temperature-sensitive mutants. Exp Parasitol. 1976 Jun;39(3):365–376. doi: 10.1016/0014-4894(76)90040-0. [DOI] [PubMed] [Google Scholar]
  11. Pfefferkorn E. R., Rebhun S., Eckel M. Characterization of an indoleamine 2,3-dioxygenase induced by gamma-interferon in cultured human fibroblasts. J Interferon Res. 1986 Jun;6(3):267–279. doi: 10.1089/jir.1986.6.267. [DOI] [PubMed] [Google Scholar]
  12. Shirahata T., Shimizu K. Growth inhibition of Toxoplasma gondii in cell cultures treated with murine type II interferon. Nihon Juigaku Zasshi. 1982 Dec;44(6):865–871. doi: 10.1292/jvms1939.44.865. [DOI] [PubMed] [Google Scholar]
  13. Suzuki Y., Orellana M. A., Schreiber R. D., Remington J. S. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science. 1988 Apr 22;240(4851):516–518. doi: 10.1126/science.3128869. [DOI] [PubMed] [Google Scholar]

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