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. 1990 Apr;58(4):1114–1116. doi: 10.1128/iai.58.4.1114-1116.1990

Trypanosoma cruzi-induced suppression of human peripheral blood lymphocytes activated via the alternative (CD2) pathway.

L A Beltz 1, F Kierszenbaum 1, M B Sztein 1
PMCID: PMC258590  PMID: 1969391

Abstract

Coculture of blood forms of Trypanosoma cruzi with human peripheral blood mononuclear cells stimulated with anti-CD2(2) and anti-CD2(3) monoclonal antibodies, i.e., via an antigen-independent pathway of T-lymphocyte activation, resulted in marked immunosuppression compared with that in parallel cultures in which parasites were absent. This effect was evidenced by a decreased lymphoproliferative capacity, a significant reduction in the proportion of cells expressing interleukin-2 receptors, and a significant diminution in the cell surface density of this receptor.

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Selected References

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