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. 1990 Jun;58(6):1932–1936. doi: 10.1128/iai.58.6.1932-1936.1990

Liposomes containing anti-idiotypic antibodies: an oral vaccine to induce protective secretory immune responses specific for pathogens of mucosal surfaces.

S Jackson 1, J Mestecky 1, N K Childers 1, S M Michalek 1
PMCID: PMC258746  PMID: 2341186

Abstract

By using a gnotobiotic rat model system to study the induction of protective immune responses by anti-idiotype (anti-id) vaccines specific for antibodies directed at the cariogenic microorganism Streptococcus mutans, it was shown that administration of such an anti-id vaccine provided partial protection against dental caries after challenge with virulent microorganisms. Protective effects were first demonstrated by direct parenteral administration of the anti-id vaccine into salivary gland regions, as determined by reductions in microbial colonization and caries scores. Subsequently, the anti-id was incorporated into liposomes and administered by gastric intubation. Immunization by this regimen also resulted in a significant reduction in caries as well as S. mutans colonization of the oral cavity, with concomitant increases in salivary immunoglobulin A anti-S. mutans antibodies. These data provide evidence that anti-id vaccines specifically targeted at the secretory immune system can induce protective immune responses to pathogens of mucosal surfaces.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Childers N. K., Michalek S. M., Denys F., McGhee J. R. Characterization of liposomes for oral vaccines. Adv Exp Med Biol. 1987;216B:1771–1780. [PubMed] [Google Scholar]
  2. Finberg R. W., Ertl H. The use of antiidiotypic antibodies as vaccines against infectious agents. Crit Rev Immunol. 1987;7(4):269–284. [PubMed] [Google Scholar]
  3. Gregory R. L., Michalek S. M., Richardson G., Harmon C., Hilton T., McGhee J. R. Characterization of immune response to oral administration of Streptococcus sobrinus ribosomal preparations in liposomes. Infect Immun. 1986 Dec;54(3):780–786. doi: 10.1128/iai.54.3.780-786.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grzych J. M., Capron M., Lambert P. H., Dissous C., Torres S., Capron A. An anti-idiotype vaccine against experimental schistosomiasis. Nature. 1985 Jul 4;316(6023):74–76. doi: 10.1038/316074a0. [DOI] [PubMed] [Google Scholar]
  5. Hamada S., Slade H. D. Biology, immunology, and cariogenicity of Streptococcus mutans. Microbiol Rev. 1980 Jun;44(2):331–384. doi: 10.1128/mr.44.2.331-384.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  7. KEYES P. H. Dental caries in the molar teeth of rats. II. A method for diagnosing and scoring several types of lesions simultaneously. J Dent Res. 1958 Nov-Dec;37(6):1088–1099. doi: 10.1177/00220345580370060901. [DOI] [PubMed] [Google Scholar]
  8. Kennedy R. C., Eichberg J. W., Lanford R. E., Dreesman G. R. Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees. Science. 1986 Apr 11;232(4747):220–223. doi: 10.1126/science.3952505. [DOI] [PubMed] [Google Scholar]
  9. Krasse B., Emilson C. G., Gahnberg L. An anticaries vaccine: report on the status of research. Caries Res. 1987;21(3):255–276. doi: 10.1159/000261029. [DOI] [PubMed] [Google Scholar]
  10. McGhee, Michalek S. M., Webb J., Navia J. M., Rahman A. F., Legler D. W. Effective immunity to dental caries: protection of gnotobiotic rats by local immunization with Streptococcus mutans. J Immunol. 1975 Jan;114(1 Pt 2):300–305. [PubMed] [Google Scholar]
  11. McNamara M. K., Ward R. E., Kohler H. Monoclonal idiotope vaccine against Streptococcus pneumoniae infection. Science. 1984 Dec 14;226(4680):1325–1326. doi: 10.1126/science.6505692. [DOI] [PubMed] [Google Scholar]
  12. Mestecky J., McGhee J. R. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv Immunol. 1987;40:153–245. doi: 10.1016/s0065-2776(08)60240-0. [DOI] [PubMed] [Google Scholar]
  13. Mestecky J., Russell M. W., Jackson S., Brown T. A. The human IgA system: a reassessment. Clin Immunol Immunopathol. 1986 Jul;40(1):105–114. doi: 10.1016/0090-1229(86)90073-5. [DOI] [PubMed] [Google Scholar]
  14. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J Clin Immunol. 1987 Jul;7(4):265–276. doi: 10.1007/BF00915547. [DOI] [PubMed] [Google Scholar]
  15. Michalek S. M., McGhee J. R., Babb J. L. Effective immunity to dental caries: dose-dependent studies of secretory immunity by oral administration of Streptococcus mutans to rats. Infect Immun. 1978 Jan;19(1):217–224. doi: 10.1128/iai.19.1.217-224.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Morisaki I., Michalek S. M., Harmon C. C., Torii M., Hamada S., McGhee J. R. Effective immunity to dental caries: enhancement of salivary anti-Streptococcus mutans antibody responses with oral adjuvants. Infect Immun. 1983 May;40(2):577–591. doi: 10.1128/iai.40.2.577-591.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Ogra P. L., Chiba Y., Beutner K. R., Morag A. Vaccination by non-parenteral routes: characteristics of immune response. Dev Biol Stand. 1976;33:19–26. [PubMed] [Google Scholar]
  18. Rodkey L. S. Autoregulation of immune responses via idiotype network interactions. Microbiol Rev. 1980 Dec;44(4):631–659. doi: 10.1128/mr.44.4.631-659.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Russell M. W. Purification and properties of a protein surface antigen of Streptococcus mutants. Microbios. 1979;25(99):7–18. [PubMed] [Google Scholar]
  20. Sacks D. L., Esser K. M., Sher A. Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies. J Exp Med. 1982 Apr 1;155(4):1108–1119. doi: 10.1084/jem.155.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Stein K. E., Söderström T. Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice. J Exp Med. 1984 Oct 1;160(4):1001–1011. doi: 10.1084/jem.160.4.1001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Uytdehaag F. G., Osterhaus A. D. Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody. J Immunol. 1985 Feb;134(2):1225–1229. [PubMed] [Google Scholar]

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