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Infection and Immunity logoLink to Infection and Immunity
. 1990 Jul;58(7):2386–2388. doi: 10.1128/iai.58.7.2386-2388.1990

Evidence that endogenous gamma interferon is produced early in Listeria monocytogenes infection.

A Nakane 1, A Numata 1, M Asano 1, M Kohanawa 1, Y Chen 1, T Minagawa 1
PMCID: PMC258824  PMID: 2114368

Abstract

It has been presumed that gamma interferon (IFN-gamma), which plays an essential role in antilisterial resistance, is produced late in Listeria monocytogenes infection. In the present study, however, IFN-gamma was detected in the bloodstreams and spleens of mice from days 1 to 4 of L. monocytogenes infection by both a double-sandwich enzyme-linked immunosorbent assay and an immunohistochemical technique, suggesting that endogenous IFN-gamma is produced early but not late in L. monocytogenes infection.

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Selected References

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