Abstract
Gastrointestinal immune events in giardiasis are important in controlling infection. In this study, Peyer's patch lymphocytes from mice infected with Giardia muris developed specific, proliferative responses to G. muris antigen. This proliferation correlated with clearance of infection. Further understanding of the gut immune response will be helpful in developing immunoprophylactic strategies in the control of giardiasis.
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- Andrews J. S., Jr, Ellner J. J., Stevens D. P. Purification of Giardia muris trophozoites by using nylon fiber columns. Am J Trop Med Hyg. 1980 Jan;29(1):12–15. doi: 10.4269/ajtmh.1980.29.12. [DOI] [PubMed] [Google Scholar]
- Bienenstock J., Befus A. D. Mucosal immunology. Immunology. 1980 Oct;41(2):249–270. [PMC free article] [PubMed] [Google Scholar]
- Carlson J. R., Heyworth M. F., Owen R. L. Response of Peyer's patch lymphocyte subsets to Giardia muris infection in BALB/c mice. I. T-cell subsets. Cell Immunol. 1986 Jan;97(1):44–50. doi: 10.1016/0008-8749(86)90373-4. [DOI] [PubMed] [Google Scholar]
- Carlson J. R., Heyworth M. F., Owen R. L. Response of Peyer's patch lymphocyte subsets to Giardia muris infection in BALB/c mice. II. B-cell subsets: enteric antigen exposure is associated with immunoglobulin isotype switching by Peyer's patch B cells. Cell Immunol. 1986 Jan;97(1):51–58. doi: 10.1016/0008-8749(86)90374-6. [DOI] [PubMed] [Google Scholar]
- Cebra J. J., Gearhart P. J., Kamat R., Robertson S. M., Tseng J. Origin and differentiation of lymphocytes involved in the secretory IgA responses. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 1):201–215. doi: 10.1101/sqb.1977.041.01.026. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Duncombe V. M., Bolin T. D., Davis A. E., Cummins A. G., Crouch R. L. Histopathology in giardiasis: a correlation with diarrhoea. Aust N Z J Med. 1978 Aug;8(4):392–396. doi: 10.1111/j.1445-5994.1978.tb04908.x. [DOI] [PubMed] [Google Scholar]
- Elson C. O., Heck J. A., Strober W. T-cell regulation of murine IgA synthesis. J Exp Med. 1979 Mar 1;149(3):632–643. doi: 10.1084/jem.149.3.632. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Elson C. O. Induction and control of the gastrointestinal immune system. Scand J Gastroenterol Suppl. 1985;114:1–15. doi: 10.3109/00365528509093764. [DOI] [PubMed] [Google Scholar]
- Frangakis M. V., Koopman W. J., Kiyono H., Michalek S. M., McGhee J. R. An enzymatic method for preparation of dissociated murine Peyer's patch cells enriched for macrophages. J Immunol Methods. 1982;48(1):33–44. doi: 10.1016/0022-1759(82)90207-1. [DOI] [PubMed] [Google Scholar]
- Heyworth M. F. Antibody response to Giardia muris trophozoites in mouse intestine. Infect Immun. 1986 May;52(2):568–571. doi: 10.1128/iai.52.2.568-571.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heyworth M. F., Carlson J. R., Ermak T. H. Clearance of Giardia muris infection requires helper/inducer T lymphocytes. J Exp Med. 1987 Jun 1;165(6):1743–1748. doi: 10.1084/jem.165.6.1743. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heyworth M. F. Intestinal IgA responses to Giardia muris in mice depleted of helper T lymphocytes and in immunocompetent mice. J Parasitol. 1989 Apr;75(2):246–251. [PubMed] [Google Scholar]
- Istre G. R., Dunlop T. S., Gaspard G. B., Hopkins R. S. Waterborne giardiasis at a mountain resort: evidence for acquired immunity. Am J Public Health. 1984 Jun;74(6):602–604. doi: 10.2105/ajph.74.6.602. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kawanishi H., Saltzman L. E., Strober W. Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. I. T cells derived from Peyer's patches that switch sIgM B cells to sIgA B cells in vitro. J Exp Med. 1983 Feb 1;157(2):433–450. doi: 10.1084/jem.157.2.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kiyono H., Cooper M. D., Kearney J. F., Mosteller L. M., Michalek S. M., Koopman W. J., McGhee J. R. Isotype specificity of helper T cell clones. Peyer's patch Th cells preferentially collaborate with mature IgA B cells for IgA responses. J Exp Med. 1984 Mar 1;159(3):798–811. doi: 10.1084/jem.159.3.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kiyono H., McGhee J. R., Wannemuehler M. J., Frangakis M. V., Spalding D. M., Michalek S. M., Koopman W. J. In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch. Proc Natl Acad Sci U S A. 1982 Jan;79(2):596–600. doi: 10.1073/pnas.79.2.596. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- MacDonald T. T., Carter P. B. Isolation and functional characteristics of adherent phagocytic cells from mouse Peyer's patches. Immunology. 1982 Apr;45(4):769–774. [PMC free article] [PubMed] [Google Scholar]
- Owen R. L., Allen C. L., Stevens D. P. Phagocytosis of Giardia muris by macrophages in Peyer's patch epithelium in mice. Infect Immun. 1981 Aug;33(2):591–601. doi: 10.1128/iai.33.2.591-601.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oyerinde J. P., Ogunbi O., Alonge A. A. Age and sex distribution of infections with Entamoeba histolytica and Giardia intestinalis in the Lagos population. Int J Epidemiol. 1977 Sep;6(3):231–234. doi: 10.1093/ije/6.3.231. [DOI] [PubMed] [Google Scholar]
- Richman L. K., Graeff A. S., Strober W. Antigen presentation by macrophage-enriched cells from the mouse Peyer's patch. Cell Immunol. 1981 Jul 15;62(1):110–118. doi: 10.1016/0008-8749(81)90304-x. [DOI] [PubMed] [Google Scholar]
- Ridley M. J., Ridley D. S. Serum antibodies and jejunal histology in giardiasis associated with malabsorption. J Clin Pathol. 1976 Jan;29(1):30–34. doi: 10.1136/jcp.29.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts-Thomson I. C., Mitchell G. F. Giardiasis in mice. I. Prolonged infections in certain mouse strains and hypothymic (nude) mice. Gastroenterology. 1978 Jul;75(1):42–46. [PubMed] [Google Scholar]
- Roberts-Thomson I. C., Stevens D. P., Mahmoud A. A., Warren K. S. Acquired resistance to infection in an animal model of giardiasis. J Immunol. 1976 Nov;117(5 PT2):2036–2037. [PubMed] [Google Scholar]
- Roberts-Thomson I. C., Stevens D. P., Mahmoud A. A., Warren K. S. Giardiasis in the mouse: an animal model. Gastroenterology. 1976 Jul;71(1):57–61. [PubMed] [Google Scholar]
- Snider D. P., Underdown B. J. Quantitative and temporal analyses of murine antibody response in serum and gut secretions to infection with Giardia muris. Infect Immun. 1986 Apr;52(1):271–278. doi: 10.1128/iai.52.1.271-278.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Targan S. R., Kagnoff M. F., Brogan M. D., Shanahan F. Immunologic mechanisms in intestinal diseases. Ann Intern Med. 1987 Jun;106(6):853–870. doi: 10.7326/0003-4819-106-6-853. [DOI] [PubMed] [Google Scholar]
- Tomasi T. B., Jr Mechanisms of immune regulation at mucosal surfaces. Rev Infect Dis. 1983 Sep-Oct;5 (Suppl 4):S784–S792. doi: 10.1093/clinids/5.supplement_4.s784. [DOI] [PubMed] [Google Scholar]
- Underdown B. J., Skea D. L., Loney G. M., Snider D. P. Murine giardiasis and mucosal immunity: a model for the study of immunity to intestinal protozoan parasites. Monogr Allergy. 1988;24:287–296. [PubMed] [Google Scholar]
- denHollander N., Riley D., Befus D. Immunology of giardiasis. Parasitol Today. 1988 May;4(5):124–131. doi: 10.1016/0169-4758(88)90186-x. [DOI] [PubMed] [Google Scholar]