Skip to main content
The Yale Journal of Biology and Medicine logoLink to The Yale Journal of Biology and Medicine
. 2002 Sep-Dec;75(5-6):313–321.

What is life? Prerequisites for a definition.

Douglas E Dix 1
PMCID: PMC2588815  PMID: 14580113

Abstract

Biologists view life as transient while theologians see it as eternal. An unbiased definition for life would respect both views until one or both were eliminated by evidence. This paper identifies pre-requisites for such a definition. First among these is that all assumptions be made explicit. Currently "life" is surrounded by implicit assumptions, e.g., that it is what organisms lose at death or that it is eternal, that its quality is inversely related to personal distress, that it originated some four billion years ago, and that animate matter can be distinguished from inanimate matter. None of these assumptions are supported by data. It is possible therefore that "life" is as meaningless as phlogiston. If life has meaning, i.e., if it is true, it must be as permanent as buoyancy, gravity, electricity, and the other truths of nature. Any definition for life that would permit such truth to be seen must be free of unwarranted assumptions. For the moment, at least, such a definition would need to be loosely structured and broadly focused. It would need to describe the long and convoluted process by which matter and energy form organisms which then evolve to form conscious organisms which then explore nature and eventually discover truth. Such a definition would include all the reactions and interactions of matter and energy and all the aspects of conscious discovery. It would suffer from superficiality, but, by being free from bias, provide a foundation for dialogue between biologists and theologians.

Full text

PDF
313

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bada Jeffrey L., Lazcano Antonio. Origin of life. Some like it hot, but not the first biomolecules. Science. 2002 Jun 14;296(5575):1982–1983. doi: 10.1126/science.1069487. [DOI] [PubMed] [Google Scholar]
  2. Battersby A. R. How nature builds the pigments of life: the conquest of vitamin B12. Science. 1994 Jun 10;264(5165):1551–1557. doi: 10.1126/science.8202709. [DOI] [PubMed] [Google Scholar]
  3. Benner Steven A., Caraco M. Daniel, Thomson J. Michael, Gaucher Eric A. Planetary biology--paleontological, geological, and molecular histories of life. Science. 2002 May 3;296(5569):864–868. doi: 10.1126/science.1069863. [DOI] [PubMed] [Google Scholar]
  4. Burton Fred. Looking at a renegade's predecessors. Science. 2002 May 17;296(5571):1237–1237. [PubMed] [Google Scholar]
  5. Chochinov Harvey Max. Dignity-conserving care--a new model for palliative care: helping the patient feel valued. JAMA. 2002 May 1;287(17):2253–2260. doi: 10.1001/jama.287.17.2253. [DOI] [PubMed] [Google Scholar]
  6. Churchland Patricia S. Self-representation in nervous systems. Science. 2002 Apr 12;296(5566):308–310. doi: 10.1126/science.1070564. [DOI] [PubMed] [Google Scholar]
  7. Dix D. A defense of vitalism. J Theor Biol. 1968 Sep;20(3):338–340. doi: 10.1016/0022-5193(68)90133-1. [DOI] [PubMed] [Google Scholar]
  8. Fedo Christopher M., Whitehouse Martin J. Metasomatic origin of quartz-pyroxene rock, Akilia, Greenland, and implications for Earth's earliest life. Science. 2002 May 24;296(5572):1448–1452. doi: 10.1126/science.1070336. [DOI] [PubMed] [Google Scholar]
  9. Fox S. W. Synthesis of life in the lab? Defining a protoliving system. Q Rev Biol. 1991 Jun;66(2):181–185. doi: 10.1086/417144. [DOI] [PubMed] [Google Scholar]
  10. Hagmann Michael. Günter Wächtershäuser profile. Between a rock and a hard place. Science. 2002 Mar 15;295(5562):2006–2007. doi: 10.1126/science.295.5562.2006. [DOI] [PubMed] [Google Scholar]
  11. Hunter G. K. Is biology reducible to chemistry? Perspect Biol Med. 1996 Autumn;40(1):130–138. doi: 10.1353/pbm.1996.0062. [DOI] [PubMed] [Google Scholar]
  12. Kerr Richard A. Paleoceanography. Inconstant ancient seas and life's path. Science. 2002 Nov 8;298(5596):1165–1166. doi: 10.1126/science.298.5596.1165. [DOI] [PubMed] [Google Scholar]
  13. Kerr Richard A. Paleontology. Earliest signs of life just oddly shaped crud? Science. 2002 Mar 8;295(5561):1812–1812. doi: 10.1126/science.295.5561.1812. [DOI] [PubMed] [Google Scholar]
  14. Korzeniewski B. Cybernetic formulation of the definition of life. J Theor Biol. 2001 Apr 7;209(3):275–286. doi: 10.1006/jtbi.2001.2262. [DOI] [PubMed] [Google Scholar]
  15. Koshland Daniel E., Jr Special essay. The seven pillars of life. Science. 2002 Mar 22;295(5563):2215–2216. doi: 10.1126/science.1068489. [DOI] [PubMed] [Google Scholar]
  16. Matzinger Polly. The danger model: a renewed sense of self. Science. 2002 Apr 12;296(5566):301–305. doi: 10.1126/science.1071059. [DOI] [PubMed] [Google Scholar]
  17. Medzhitov Ruslan, Janeway Charles A., Jr Decoding the patterns of self and nonself by the innate immune system. Science. 2002 Apr 12;296(5566):298–300. doi: 10.1126/science.1068883. [DOI] [PubMed] [Google Scholar]
  18. Oltvai Zoltán N., Barabási Albert-László. Systems biology. Life's complexity pyramid. Science. 2002 Oct 25;298(5594):763–764. doi: 10.1126/science.1078563. [DOI] [PubMed] [Google Scholar]
  19. Pennisi E. Human genome. Finally, the book of life and instructions for navigating it. Science. 2000 Jun 30;288(5475):2304–2307. doi: 10.1126/science.288.5475.2304. [DOI] [PubMed] [Google Scholar]
  20. Prutkin Jordan M., Feinstein Alvan R. Quality-of-life measurements: origin and pathogenesis. Yale J Biol Med. 2002 Mar-Apr;75(2):79–93. [PMC free article] [PubMed] [Google Scholar]
  21. Ruse Michael. Perceptions in science. Is evolution a secular religion? Science. 2003 Mar 7;299(5612):1523–1524. doi: 10.1126/science.1082968. [DOI] [PubMed] [Google Scholar]
  22. Seife Charles. The intelligent noncosmologist's guide to spacetime. Science. 2002 May 24;296(5572):1418–1421. doi: 10.1126/science.296.5572.1418. [DOI] [PubMed] [Google Scholar]
  23. Steinhardt Paul J., Turok Neil. A cyclic model of the universe. Science. 2002 Apr 25;296(5572):1436–1439. doi: 10.1126/science.1070462. [DOI] [PubMed] [Google Scholar]
  24. Tannenbaum A. S. The sense of consciousness. J Theor Biol. 2001 Aug 21;211(4):377–391. doi: 10.1006/jtbi.2001.2355. [DOI] [PubMed] [Google Scholar]
  25. Weeks Jane C., Nelson Heidi, Gelber Shari, Sargent Daniel, Schroeder Georgene, Clinical Outcomes of Surgical Therapy (COST) Study Group Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial. JAMA. 2002 Jan 16;287(3):321–328. doi: 10.1001/jama.287.3.321. [DOI] [PubMed] [Google Scholar]
  26. Zens M. Scot, Webb Campbell O. Ecology. Sizing up the shape of life. Science. 2002 Feb 22;295(5559):1475–1476. doi: 10.1126/science.1070130. [DOI] [PubMed] [Google Scholar]

Articles from The Yale Journal of Biology and Medicine are provided here courtesy of Yale Journal of Biology and Medicine

RESOURCES