Skip to main content
The Yale Journal of Biology and Medicine logoLink to The Yale Journal of Biology and Medicine
. 1993 Nov-Dec;66(6):511–524.

Genetic fatalism and social policy: the implications of behavior genetics research.

J S Alper 1, J Beckwith 1
PMCID: PMC2588854  PMID: 7716971

Abstract

Recent advances in molecular genetics methods have provided new means of determining the genetic bases of human behavioral traits. The impetus for the use of these approaches for specific behaviors depends, in large part, on previous familial studies on inheritance of such traits. In the past, a finding of a genetic basis for a trait was often accompanied with the idea that that trait is unchangeable. We discuss the definition of "genetic trait" and heritability and examine the relationship between these concepts and the malleability of traits for both molecular and nonmolecular approaches to behavioral genetics. We argue that the malleability of traits is as much a social and political question as it is a biological one and that whether or not a trait is genetic has little relevance to questions concerning determinism, free will, and individual responsibility for actions. We conclude by noting that "scientific objectivity" should not be used to conceal the social perspectives that underlie proposals regarding social change.

Full text

PDF
511

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group. Cell. 1993 Mar 26;72(6):971–983. doi: 10.1016/0092-8674(93)90585-e. [DOI] [PubMed] [Google Scholar]
  2. Alper J. S., Natowicz M. R. On establishing the genetic basis of mental disease. Trends Neurosci. 1993 Oct;16(10):387–389. doi: 10.1016/0166-2236(93)90003-5. [DOI] [PubMed] [Google Scholar]
  3. Bailey J. M., Pillard R. C. A genetic study of male sexual orientation. Arch Gen Psychiatry. 1991 Dec;48(12):1089–1096. doi: 10.1001/archpsyc.1991.01810360053008. [DOI] [PubMed] [Google Scholar]
  4. Barnes D. M. Troubles encountered in gene linkage land. Science. 1989 Jan 20;243(4889):313–314. doi: 10.1126/science.2911743. [DOI] [PubMed] [Google Scholar]
  5. Baron M., Endicott J., Ott J. Genetic linkage in mental illness. Limitations and prospects. Br J Psychiatry. 1990 Nov;157:645–655. doi: 10.1192/bjp.157.5.645. [DOI] [PubMed] [Google Scholar]
  6. Baron M., Freimer N. F., Risch N., Lerer B., Alexander J. R., Straub R. E., Asokan S., Das K., Peterson A., Amos J. Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Nat Genet. 1993 Jan;3(1):49–55. doi: 10.1038/ng0193-49. [DOI] [PubMed] [Google Scholar]
  7. Billings P. R., Beckwith J., Alper J. S. The genetic analysis of human behavior: a new era? Soc Sci Med. 1992 Aug;35(3):227–238. doi: 10.1016/0277-9536(92)90019-m. [DOI] [PubMed] [Google Scholar]
  8. Bouchard T. J., Jr, Lykken D. T., McGue M., Segal N. L., Tellegen A. Sources of human psychological differences: the Minnesota Study of Twins Reared Apart. Science. 1990 Oct 12;250(4978):223–228. doi: 10.1126/science.2218526. [DOI] [PubMed] [Google Scholar]
  9. Bouchard T. J., Jr, McGue M. Familial studies of intelligence: a review. Science. 1981 May 29;212(4498):1055–1059. doi: 10.1126/science.7195071. [DOI] [PubMed] [Google Scholar]
  10. Brunner H. G., Nelen M., Breakefield X. O., Ropers H. H., van Oost B. A. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science. 1993 Oct 22;262(5133):578–580. doi: 10.1126/science.8211186. [DOI] [PubMed] [Google Scholar]
  11. Chartier-Harlin M. C., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene. Nature. 1991 Oct 31;353(6347):844–846. doi: 10.1038/353844a0. [DOI] [PubMed] [Google Scholar]
  12. Ciaranello R. D., Ciaranello A. L. Genetics of major psychiatric disorders. Annu Rev Med. 1991;42:151–158. doi: 10.1146/annurev.me.42.020191.001055. [DOI] [PubMed] [Google Scholar]
  13. Cloninger C. R. Neurogenetic adaptive mechanisms in alcoholism. Science. 1987 Apr 24;236(4800):410–416. doi: 10.1126/science.2882604. [DOI] [PubMed] [Google Scholar]
  14. Collins F. S. The Genome Project and human health. FASEB J. 1991 Jan;5(1):77–77. doi: 10.1096/fasebj.5.1.1991592. [DOI] [PubMed] [Google Scholar]
  15. Egeland J. A., Gerhard D. S., Pauls D. L., Sussex J. N., Kidd K. K., Allen C. R., Hostetter A. M., Housman D. E. Bipolar affective disorders linked to DNA markers on chromosome 11. 1987 Feb 26-Mar 4Nature. 325(6107):783–787. doi: 10.1038/325783a0. [DOI] [PubMed] [Google Scholar]
  16. Gershon E. S., Martinez M., Goldin L. R., Gejman P. V. Genetic mapping of common diseases: the challenges of manic-depressive illness and schizophrenia. Trends Genet. 1990 Sep;6(9):282–287. doi: 10.1016/0168-9525(90)90233-v. [DOI] [PubMed] [Google Scholar]
  17. Graham L. R. Science and values: the eugenics movement in Germany and Russia in the 1920s. Am Hist Rev. 1977 Dec;82(5):1133–1164. [PubMed] [Google Scholar]
  18. Gusella J. F., Wexler N. S., Conneally P. M., Naylor S. L., Anderson M. A., Tanzi R. E., Watkins P. C., Ottina K., Wallace M. R., Sakaguchi A. Y. A polymorphic DNA marker genetically linked to Huntington's disease. Nature. 1983 Nov 17;306(5940):234–238. doi: 10.1038/306234a0. [DOI] [PubMed] [Google Scholar]
  19. Hamer D. H., Hu S., Magnuson V. L., Hu N., Pattatucci A. M. A linkage between DNA markers on the X chromosome and male sexual orientation. Science. 1993 Jul 16;261(5119):321–327. doi: 10.1126/science.8332896. [DOI] [PubMed] [Google Scholar]
  20. Holden C. Alcoholism gene: coming or going? Science. 1991 Oct 11;254(5029):200–200. doi: 10.1126/science.254.5029.200. [DOI] [PubMed] [Google Scholar]
  21. INGRAM V. M. Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin. Nature. 1957 Aug 17;180(4581):326–328. doi: 10.1038/180326a0. [DOI] [PubMed] [Google Scholar]
  22. Kolata G. B. Math and sex: are girls born with less ability? Science. 1980 Dec 12;210(4475):1234–1235. doi: 10.1126/science.7434024. [DOI] [PubMed] [Google Scholar]
  23. Kolata G. Panel urges newborn sickle cell screening. Science. 1987 Apr 17;236(4799):259–260. doi: 10.1126/science.3563504. [DOI] [PubMed] [Google Scholar]
  24. Koshland D. E., Jr Sequences and consequences of the human genome. Science. 1989 Oct 13;246(4927):189–189. doi: 10.1126/science.2799380. [DOI] [PubMed] [Google Scholar]
  25. LeVay S. A difference in hypothalamic structure between heterosexual and homosexual men. Science. 1991 Aug 30;253(5023):1034–1037. doi: 10.1126/science.1887219. [DOI] [PubMed] [Google Scholar]
  26. McNamara J. O., Fridovich I. Human genetics. Did radicals strike Lou Gehrig? Nature. 1993 Mar 4;362(6415):20–21. doi: 10.1038/362020a0. [DOI] [PubMed] [Google Scholar]
  27. Murrell J., Farlow M., Ghetti B., Benson M. D. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science. 1991 Oct 4;254(5028):97–99. doi: 10.1126/science.1925564. [DOI] [PubMed] [Google Scholar]
  28. Noble E. P., Blum K., Ritchie T., Montgomery A., Sheridan P. J. Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism. Arch Gen Psychiatry. 1991 Jul;48(7):648–654. doi: 10.1001/archpsyc.1991.01810310066012. [DOI] [PubMed] [Google Scholar]
  29. Owen M. J. Will schizophrenia become a graveyard for molecular geneticists? Psychol Med. 1992 May;22(2):289–293. doi: 10.1017/s0033291700030221. [DOI] [PubMed] [Google Scholar]
  30. Plomin R. The role of inheritance in behavior. Science. 1990 Apr 13;248(4952):183–188. doi: 10.1126/science.2183351. [DOI] [PubMed] [Google Scholar]
  31. Riordan J. R., Rommens J. M., Kerem B., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsic N., Chou J. L. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 1989 Sep 8;245(4922):1066–1073. doi: 10.1126/science.2475911. [DOI] [PubMed] [Google Scholar]
  32. Risch N. Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genet Epidemiol. 1990;7(1):3–45. doi: 10.1002/gepi.1370070103. [DOI] [PubMed] [Google Scholar]
  33. Schiff M., Duyme M., Dumaret A., Stewart J., Tomkiewicz S., Feingold J. Intellectual status of working-class children adopted early into upper-middle-class families. Science. 1978 Jun 30;200(4349):1503–1504. doi: 10.1126/science.663634. [DOI] [PubMed] [Google Scholar]
  34. Searles J. S. The role of genetics in the pathogenesis of alcoholism. J Abnorm Psychol. 1988 May;97(2):153–167. doi: 10.1037//0021-843x.97.2.153. [DOI] [PubMed] [Google Scholar]
  35. Sherrington R., Brynjolfsson J., Petursson H., Potter M., Dudleston K., Barraclough B., Wasmuth J., Dobbs M., Gurling H. Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature. 1988 Nov 10;336(6195):164–167. doi: 10.1038/336164a0. [DOI] [PubMed] [Google Scholar]
  36. St George-Hyslop P. H., Tanzi R. E., Polinsky R. J., Haines J. L., Nee L., Watkins P. C., Myers R. H., Feldman R. G., Pollen D., Drachman D. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science. 1987 Feb 20;235(4791):885–890. doi: 10.1126/science.2880399. [DOI] [PubMed] [Google Scholar]
  37. Watt D. C., Edwards J. H. Doubt about evidence for a schizophrenia gene on chromosome 5. Psychol Med. 1991 May;21(2):279–285. doi: 10.1017/s0033291700020365. [DOI] [PubMed] [Google Scholar]

Articles from The Yale Journal of Biology and Medicine are provided here courtesy of Yale Journal of Biology and Medicine

RESOURCES