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. 1996 Jan-Feb;69(1):85–90.

Peptic activity and gastroduodenal mucosal damage.

J P Raufman 1
PMCID: PMC2588974  PMID: 9041694

Abstract

This contribution reviews briefly the history of the discovery and characterization of peptic activity; secretory models and current concepts regarding the regulation of pepsinogen secretion; and evidence that pepsin is a necessary co-factor for gastroduodenal mucosal injury. Several animal studies indicate that peptic activity is required for acid- and nonsteroidal anti-inflammatory drug-induced gastroduodenal ulceration. A more vigorous approach to the development of anti-peptic drugs for the treatment of peptic ulcer disease is encouraged.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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