Skip to main content
NCBI home page
The Yale Journal of Biology and Medicine logoLink to The Yale Journal of Biology and Medicine
. 1996 Jul-Aug;69(4):317–321.

Cystic fibrosis and calcium oxalate nephrolithiasis.

A S Chidekel 1, T F Dolan Jr 1
PMCID: PMC2589049  PMID: 9273985

Abstract

During the past six years, we have treated eight patients with cystic fibrosis (CF) for nephrolithiasis. In seven patients, the stones were comprised of calcium oxalate. Another six patients had calcium oxalate crystalluria. In our CF population of 140 patients, this represents a cumulative incidence of calcium oxalate nephrolithiasis of 5.7 percent and an additional 4.2 percent incidence of crystalluria. Experience with these patients is reviewed. Pancreatic insufficiency was universally associated with nephrolithiasis or crystalluria. Diabetes and cirrhosis were also common. Predisposing factors and potential mechanisms of stone disease in pancreatic insufficient CF patients are discussed, focusing on the relationship between fat malabsorption in CF to oxalate metabolism.

Full text

PDF
317

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bentur L., Kerem E., Couper R., Baumal R., Canny G., Durie P., Levison H. Renal calcium handling in cystic fibrosis: lack of evidence for a primary renal defect. J Pediatr. 1990 Apr;116(4):556–560. doi: 10.1016/s0022-3476(05)81602-6. [DOI] [PubMed] [Google Scholar]
  2. Binder H. J. Intestinal oxalate absorption. Gastroenterology. 1974 Sep;67(3):441–446. [PubMed] [Google Scholar]
  3. Broadus A. E., Thier S. O. Metabolic basis of renal-stone disease. N Engl J Med. 1979 Apr 12;300(15):839–845. doi: 10.1056/NEJM197904123001507. [DOI] [PubMed] [Google Scholar]
  4. Chadwick V. S., Modha K., Dowling R. H. Mechanism for hyperoxaluria in patients with ileal dysfunction. N Engl J Med. 1973 Jul 26;289(4):172–176. doi: 10.1056/NEJM197307262890402. [DOI] [PubMed] [Google Scholar]
  5. Dobbins J. W., Binder H. J. Effect of bile salts and fatty acids on the colonic absorption of oxalate. Gastroenterology. 1976 Jun;70(6):1096–1100. [PubMed] [Google Scholar]
  6. Dobbins J. W., Binder H. J. Importance of the colon in enteric hyperoxaluria. N Engl J Med. 1977 Feb 10;296(6):298–301. doi: 10.1056/NEJM197702102960602. [DOI] [PubMed] [Google Scholar]
  7. Earnest D. L., Johnson G., Williams H. E., Admirand W. H. Hyperoxaluria in patients with ileal resection: an abnormality in dietary oxalate absorption. Gastroenterology. 1974 Jun;66(6):1114–1122. [PubMed] [Google Scholar]
  8. Gearhart J. P., Herzberg G. Z., Jeffs R. D. Childhood urolithiasis: experiences and advances. Pediatrics. 1991 Apr;87(4):445–450. [PubMed] [Google Scholar]
  9. Harries J. T., Muller D. P., McCollum J. P., Lipson A., Roma E., Norman A. P. Intestinal bile salts in cystic fibrosis: studies in the patient and experimental animal. Arch Dis Child. 1979 Jan;54(1):19–24. doi: 10.1136/adc.54.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hofmann A. F., Laker M. F., Dharmsathaphorn K., Sherr H. P., Lorenzo D. Complex pathogenesis of hyperoxaluria after jejunoileal bypass surgery. Oxalogenic substances in diet contribute to urinary oxalate. Gastroenterology. 1983 Feb;84(2):293–300. [PubMed] [Google Scholar]
  11. Hofmann A. F., Tacker M. M., Fromm H., Thomas P. J., Smith L. H. Acquired hyperoxaluria and intestinal disease. Evidence that bile acid glycine is not a precursor of oxalate. Mayo Clin Proc. 1973 Jan;48(1):35–42. [PubMed] [Google Scholar]
  12. Katz S. M., Krueger L. J., Falkner B. Microscopic nephrocalcinosis in cystic fibrosis. N Engl J Med. 1988 Aug 4;319(5):263–266. doi: 10.1056/NEJM198808043190502. [DOI] [PubMed] [Google Scholar]
  13. Nouisa-Arvanitakis S., Stapleton F. B., Linshaw M. A., Kennedy J. Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. J Pediatr. 1977 Feb;90(2):302–305. doi: 10.1016/s0022-3476(77)80657-4. [DOI] [PubMed] [Google Scholar]
  14. Smith L. H., Fromm H., Hofmann A. F. Acquired hyperoxaluria, nephrolithiasis, and intestinal disease. Description of a syndrome. N Engl J Med. 1972 Jun 29;286(26):1371–1375. doi: 10.1056/NEJM197206292862601. [DOI] [PubMed] [Google Scholar]
  15. Stapleton F. B., Kennedy J., Nousia-Arvanitakis S., Linshaw M. A. Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. N Engl J Med. 1976 Jul 29;295(5):246–248. doi: 10.1056/NEJM197607292950503. [DOI] [PubMed] [Google Scholar]
  16. Strandvik B., Hjelte L. Nephrolithiasis in cystic fibrosis. Acta Paediatr. 1993 Mar;82(3):306–307. doi: 10.1111/j.1651-2227.1993.tb12667.x. [DOI] [PubMed] [Google Scholar]
  17. Troup C. W., Lawnicki C. C., Bourne R. B., Hodgson N. B. Renal calculus in children. J Urol. 1972 Feb;107(2):306–307. doi: 10.1016/s0022-5347(17)61011-5. [DOI] [PubMed] [Google Scholar]
  18. Walther P. C., Lamm D., Kaplan G. W. Pediatric urolithiases: a ten-year review. Pediatrics. 1980 Jun;65(6):1068–1072. [PubMed] [Google Scholar]
  19. Wharton R., D'Agati V., Magun A. M., Whitlock R., Kunis C. L., Appel G. B. Acute deterioration of renal function associated with enteric hyperoxaluria. Clin Nephrol. 1990 Sep;34(3):116–121. [PubMed] [Google Scholar]

Articles from The Yale Journal of Biology and Medicine are provided here courtesy of Yale Journal of Biology and Medicine

RESOURCES