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. 1989 Nov-Dec;62(6):579–593.

Molecular aspects of extracorporeal photochemotherapy.

F P Gasparro 1, R Dall'Amico 1, D Goldminz 1, E Simmons 1, D Weingold 1
PMCID: PMC2589151  PMID: 2700057

Abstract

8-methoxypsoralen (8-MOP), activated upon exposure to long-wavelength ultraviolet radiation, is used therapeutically to treat the diseased blood cells of cutaneous T-cell lymphoma patients. The factors responsible for the efficacy of this therapy are reviewed. Primary among these are the plasma level of 8-MOP at the time of irradiation and the effective dose of UVA. 8-MOP plasma levels determined in a series of six patients demonstrated that the drug is absorbed at a highly variable rate (122 ng/ml +/- 67). A new liquid form of 8-MOP is absorbed with a modest increase in plasma levels (170 ng/ml) but with no improvement in the variability (+/- 163). An examination of the dose-response relationship between 8-MOP concentration and UVA dose indicated that properties such as 8-MOP photoadduct formation and PHA response are proportional to the combined doses of these two factors. A new molecular target for 8-MOP photomodification, cell membrane DNA, is described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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