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. 1990 Jan-Feb;63(1):29–46.

Research on smoking and lung cancer: a landmark in the history of chronic disease epidemiology.

C White 1
PMCID: PMC2589239  PMID: 2192501

Abstract

This paper describes the history of the epidemiologic research on lung cancer prior to 1970 and its effect on chronic disease epidemiology. In the 1930s, epidemiology was largely concerned with acute infectious diseases. As the evidence grew that the incidence of lung cancer was increasing among men, however, epidemiologists undertook research into the etiology of the disease. In 1950, Doll and Hill, in England, and Wynder and Graham, in the United States, published substantial case-control studies that implicated the use of tobacco as a major risk factor for the disease. A controversy developed over the credibility of this finding and was increased in 1954 when a cohort study by Doll and Hill and another by Hammond and Horn each gave estimates that the risk of lung cancer was greatly increased among smokers relative to the risk among comparable non-smokers. An account is given of the disputes surrounding these and related studies. The controversy had a stimulating effect in fostering the developing discipline of chronic disease and epidemiology.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERKSON J. Smoking and cancer of the lung. Proc Staff Meet Mayo Clin. 1960 Jun 22;35:367–385. [PubMed] [Google Scholar]
  2. BERKSON J. The statistical study of association between smoking and lung cancer. Proc Staff Meet Mayo Clin. 1955 Jul 27;30(15):319–348. [PubMed] [Google Scholar]
  3. BURNEY L. E. Smoking and lung cancer: a statement of the Public Health Service. J Am Med Assoc. 1959 Nov 28;171:1829–1837. doi: 10.1001/jama.1959.73010310005016. [DOI] [PubMed] [Google Scholar]
  4. Burch P. R. Lung cancer and smoking: is there proof. Br Med J. 1976 Sep 11;2(6036):640–640. doi: 10.1136/bmj.2.6036.640-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CASE R. A., HOSKER M. E., McDONALD D. B., PEARSON J. T. Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. I. The role of aniline, benzidine, alpha-naphthylamine, and beta-naphthylamine. Br J Ind Med. 1954 Apr;11(2):75–104. doi: 10.1136/oem.11.2.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. CLEMMESEN J. Bronchial carcinoma, a pandemic. Dan Med Bull. 1954 Apr;1(2):37–46. [PubMed] [Google Scholar]
  7. CORNFIELD J. A method of estimating comparative rates from clinical data; applications to cancer of the lung, breast, and cervix. J Natl Cancer Inst. 1951 Jun;11(6):1269–1275. [PubMed] [Google Scholar]
  8. CORNFIELD J., HAENSZEL W., HAMMOND E. C., LILIENFELD A. M., SHIMKIN M. B., WYNDER E. L. Smoking and lung cancer: recent evidence and a discussion of some questions. J Natl Cancer Inst. 1959 Jan;22(1):173–203. [PubMed] [Google Scholar]
  9. Cairns J. The origin of human cancers. Nature. 1981 Jan 29;289(5796):353–357. doi: 10.1038/289353a0. [DOI] [PubMed] [Google Scholar]
  10. DAWBER T. R., KANNEL W. B., REVOTSKIE N., STOKES J., 3rd, KAGAN A., GORDON T. Some factors associated with the development of coronary heart disease: six years' follow-up experience in the Framingham study. Am J Public Health Nations Health. 1959 Oct;49:1349–1356. doi: 10.2105/ajph.49.10.1349. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. DAWBER T. R., MOORE F. E., MANN G. V. Coronary heart disease in the Framingham study. Am J Public Health Nations Health. 1957 Apr;47(4 Pt 2):4–24. doi: 10.2105/ajph.47.4_pt_2.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. DOLL R., HILL A. B. A study of the aetiology of carcinoma of the lung. Br Med J. 1952 Dec 13;2(4797):1271–1286. doi: 10.1136/bmj.2.4797.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. DOLL R., HILL A. B. Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors. Br Med J. 1956 Nov 10;2(5001):1071–1081. doi: 10.1136/bmj.2.5001.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. DOLL R., HILL A. B. Smoking and carcinoma of the lung; preliminary report. Br Med J. 1950 Sep 30;2(4682):739–748. doi: 10.1136/bmj.2.4682.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. DOLL R., HILL A. B. The mortality of doctors in relation to their smoking habits; a preliminary report. Br Med J. 1954 Jun 26;1(4877):1451–1455. doi: 10.1136/bmj.1.4877.1451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. DORN H. F. Tobacco consumption and mortality from cancer and other diseases. Public Health Rep. 1959 Jul;74(7):581–593. [PMC free article] [PubMed] [Google Scholar]
  17. DOYLE J. T., DAWBER T. R., KANNEL W. B., HESLIN A. S., KAHN H. A. Cigarette smoking and coronary heart disease. Combined experience of the Albany and Framingham studies. N Engl J Med. 1962 Apr 19;266:796–801. doi: 10.1056/nejm196204192661602. [DOI] [PubMed] [Google Scholar]
  18. Doll R. Landmark perspective: Smoking and death rates. JAMA. 1984 Jun 1;251(21):2854–2857. [PubMed] [Google Scholar]
  19. E. CLIFFORD BEALE. Br Med J. 1953 Feb 7;1(4805):339–339. [PMC free article] [PubMed] [Google Scholar]
  20. FISHER R. A. Cancer and smoking. Nature. 1958 Aug 30;182(4635):596–596. doi: 10.1038/182596a0. [DOI] [PubMed] [Google Scholar]
  21. Frost W. H. Risk of Persons in Familial Contact with Pulmonary Tuberculosis. Am J Public Health Nations Health. 1933 May;23(5):426–432. doi: 10.2105/ajph.23.5.426. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. HAMMOND E. C., HORN D. Smoking and death rates; report on forty-four months of follow-up of 187,783 men. I. Total mortality. J Am Med Assoc. 1958 Mar 8;166(10):1159–1172. doi: 10.1001/jama.1958.02990100047009. [DOI] [PubMed] [Google Scholar]
  23. HAMMOND E. C., HORN D. The relationship between human smoking habits and death rates: a follow-up study of 187,766 men. J Am Med Assoc. 1954 Aug 7;155(15):1316–1328. doi: 10.1001/jama.1954.03690330020006. [DOI] [PubMed] [Google Scholar]
  24. HAMMOND E. C. Smoking in relation to lung cancer. Conn State Med J. 1954 Jan;18(1):3–9. [PubMed] [Google Scholar]
  25. HILL A. B., DOLL R. Lung cancer and tobacco; the B.M.J.'s questions answered. Br Med J. 1956 May 19;1(4976):1160–1163. doi: 10.1136/bmj.1.4976.1160. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. LILIENFELD A. M. On the methodology of investigations of etiologic factors in chronic diseases: some comments. J Chronic Dis. 1959 Jul;10(1):41–46. doi: 10.1016/0021-9681(59)90016-5. [DOI] [PubMed] [Google Scholar]
  27. LITTLE C. C. Some phases of the problem of smoking and lung cancer. N Engl J Med. 1961 Jun 15;264:1241–1245. doi: 10.1056/NEJM196106152642406. [DOI] [PubMed] [Google Scholar]
  28. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  32. SADOWSKY D. A., GILLIAM A. G., CORNFIELD J. The statistical association between smoking and carcinoma of the lung. J Natl Cancer Inst. 1953 Apr;13(5):1237–1258. [PubMed] [Google Scholar]
  33. SARTWELL P. E. "On the methodology of investigations of etiologic factors in chronic diseases"--further comments. J Chronic Dis. 1960 Jan;11:61–63. doi: 10.1016/0021-9681(60)90140-5. [DOI] [PubMed] [Google Scholar]
  34. SCOTT R. B. Some medical aspects of tobacco-smoking. Br Med J. 1952 Mar 29;1(4760):671–675. doi: 10.1136/bmj.1.4760.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. STEINER P. E., BUTT E. M., EDMONDSON H. A. Pulmonary carcinoma revealed at necropsy, with reference to increasing incidence in the Los Angeles County Hospital. J Natl Cancer Inst. 1950 Dec;11(3):497–510. [PubMed] [Google Scholar]
  36. Vandenbroucke J. P. Those who were wrong. Am J Epidemiol. 1989 Jul;130(1):3–5. doi: 10.1093/oxfordjournals.aje.a115320. [DOI] [PubMed] [Google Scholar]
  37. WYNDER E. L. An appraisal of the smoking-lung-cancer issue. N Engl J Med. 1961 Jun 15;264:1235–1240. doi: 10.1056/NEJM196106152642405. [DOI] [PubMed] [Google Scholar]
  38. WYNDER E. L., GRAHAM E. A. Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma; a study of 684 proved cases. J Am Med Assoc. 1950 May 27;143(4):329–336. doi: 10.1001/jama.1950.02910390001001. [DOI] [PubMed] [Google Scholar]
  39. Wald N. J., Idle M., Boreham J., Bailey A. Inhaling and lung cancer: an anomaly explained. Br Med J (Clin Res Ed) 1983 Oct 29;287(6401):1273–1275. doi: 10.1136/bmj.287.6401.1273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. YERUSHALMY J., PALMER C. E. On the methodology of investigations of etiologic factors in chronic diseases. J Chronic Dis. 1959 Jul;10(1):27–40. doi: 10.1016/0021-9681(59)90015-3. [DOI] [PubMed] [Google Scholar]

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