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. 1990 Jan-Feb;63(1):9–13.

Fatal subcutaneous aspergillosis following necrotizing fasciitis: a case report.

A R Falsey 1, R D Goldsticker 1, M J Ahern 1
PMCID: PMC2589255  PMID: 2356626

Abstract

Skin or subcutaneous infection with aspergillus is uncommon. It has been described in disseminated aspergillosis, as localized infection in the immunocompromised host and as a complication of trauma and burns. Described in this paper is a diabetic patient who developed a fatal Aspergillus infection following debridement of a necrotizing fasciitis. "Fruiting bodies," rarely found in vivo, were seen on pathologic examination of subcutaneous tissue. Her course was similar to that of burn patients with invasive fungal disease, where mortality is high and radical debridement is the only chance for cure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allo M. D., Miller J., Townsend T., Tan C. Primary cutaneous aspergillosis associated with Hickman intravenous catheters. N Engl J Med. 1987 Oct 29;317(18):1105–1108. doi: 10.1056/NEJM198710293171802. [DOI] [PubMed] [Google Scholar]
  2. Bruck H. M., Nash G., Foley D., Pruitt B. A., Jr Opportunistic fungal infection of the burn wound with phycomycetes and Aspergillus. A clinical-pathologic review. Arch Surg. 1971 May;102(5):476–482. doi: 10.1001/archsurg.1971.01350050042014. [DOI] [PubMed] [Google Scholar]
  3. Bruck H. M., Nash G., Stein J. M., Lindberg R. B. Studies on the occurrence and significance of yeasts and fungi in the burn wound. Ann Surg. 1972 Jul;176(1):108–110. doi: 10.1097/00000658-197207000-00019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CHEETHAM H. D. SUBCUTANEOUS INFECTION DUE TO ASPERGILLUS TERREUS. J Clin Pathol. 1964 May;17:251–253. doi: 10.1136/jcp.17.3.251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cahill K. M., Mofty A. M., Kawaguchi T. P. Primary cutaneous aspergillosis. Arch Dermatol. 1967 Nov;96(5):545–547. [PubMed] [Google Scholar]
  6. Carlile J. R., Millet R. E., Cho C. T., Vats T. S. Primary cutaneous aspergillosis in a leukemic child. Arch Dermatol. 1978 Jan;114(1):78–80. [PubMed] [Google Scholar]
  7. D'Silva H., Burke J. F., Jr, Cho S. Y. Disseminated aspergillosis in a presumably immunocompetent host. JAMA. 1982 Sep 24;248(12):1495–1497. [PubMed] [Google Scholar]
  8. Estes S. A., Hendricks A. A., Merz W. G., Prystowsky S. D. Primary cutaneous aspergillosis. J Am Acad Dermatol. 1980 Oct;3(4):397–400. doi: 10.1016/s0190-9622(80)80334-3. [DOI] [PubMed] [Google Scholar]
  9. Fisher B. D., Armstrong D., Yu B., Gold J. W. Invasive aspergillosis. Progress in early diagnosis and treatment. Am J Med. 1981 Oct;71(4):571–577. doi: 10.1016/0002-9343(81)90208-4. [DOI] [PubMed] [Google Scholar]
  10. Grossman M. E., Fithian E. C., Behrens C., Bissinger J., Fracaro M., Neu H. C. Primary cutaneous aspergillosis in six leukemic children. J Am Acad Dermatol. 1985 Feb;12(2 Pt 1):313–318. doi: 10.1016/s0190-9622(85)80042-6. [DOI] [PubMed] [Google Scholar]
  11. Karam G. H., Griffin F. M., Jr Invasive pulmonary aspergillosis in nonimmunocompromised, nonneutropenic hosts. Rev Infect Dis. 1986 May-Jun;8(3):357–363. doi: 10.1093/clinids/8.3.357. [DOI] [PubMed] [Google Scholar]
  12. Langlois R. P., Flegel K. M., Meakins J. L., Morehouse D. D., Robson H. G., Guttmann R. D. Cutaneous aspergillosis with fatal dissemination in a renal transplant recipient. Can Med Assoc J. 1980 Mar 22;122(6):673–676. [PMC free article] [PubMed] [Google Scholar]
  13. Nash G., Foley F. D., Goodwin M. N., Jr, Bruck H. M., Greenwald K. A., Pruitt B. A., Jr Fungal burn wound infection. JAMA. 1971 Mar 8;215(10):1664–1666. [PubMed] [Google Scholar]
  14. Panke T. W., McManus A. T., Jr, McLeod C. G., Jr "Fruiting bodies" of aspergillus on the skin of a burned patient. Am J Clin Pathol. 1978 Feb;69(2):188–189. doi: 10.1093/ajcp/69.2.188. [DOI] [PubMed] [Google Scholar]
  15. Patterson J. E., Barden G. E., Bia F. J. Hospital-acquired gangrenous mucormycosis. Yale J Biol Med. 1986 Jul-Aug;59(4):453–459. [PMC free article] [PubMed] [Google Scholar]
  16. Prystowsky S. D., Vogelstein B., Ettinger D. S., Merz W. G., Kaizer H., Sulica V. I., Zinkham W. H. Invasive aspergillosis. N Engl J Med. 1976 Sep 16;295(12):655–658. doi: 10.1056/NEJM197609162951206. [DOI] [PubMed] [Google Scholar]
  17. Salisbury R. E., Silverstein P., Goodwin M. N., Jr Upper extremity fungal invasions secondary to large burns. Plast Reconstr Surg. 1974 Dec;54(6):654–659. doi: 10.1097/00006534-197412000-00005. [DOI] [PubMed] [Google Scholar]
  18. Stone H. H., Cuzzell J. Z., Kolb L. D., Moskowitz M. S., McGowan J. E., Jr Aspergillus infection of the burn wound. J Trauma. 1979 Oct;19(10):765–767. doi: 10.1097/00005373-197910000-00008. [DOI] [PubMed] [Google Scholar]
  19. Suseelan A. V., Gugnani H. C., Ojukwu J. O. Letter: Primary cutaneous aspergillosis due to Aspergillus terreus. Arch Dermatol. 1976 Oct;112(10):1468–1468. [PubMed] [Google Scholar]
  20. Vainrub B., Macareno A., Mandel S., Musher D. M. Wound zygomycosis (mucormycosis) in otherwise healthy adults. Am J Med. 1988 Mar;84(3 Pt 1):546–548. doi: 10.1016/0002-9343(88)90282-3. [DOI] [PubMed] [Google Scholar]
  21. Young R. C., Bennett J. E., Vogel C. L., Carbone P. P., DeVita V. T. Aspergillosis. The spectrum of the disease in 98 patients. Medicine (Baltimore) 1970 Mar;49(2):147–173. doi: 10.1097/00005792-197003000-00002. [DOI] [PubMed] [Google Scholar]

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