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. 1992 Jan-Feb;65(1):17–28.

Biological and clinical aspects of autoimmune inner ear disease.

A J Griffith 1
PMCID: PMC2589381  PMID: 1509781

Abstract

The clinical presentation, diagnosis, and management of autoimmune inner ear disease are reviewed. Recent studies indicating an autoimmune etiology and pathogenesis are discussed, along with a comparative analysis of several promising new animal models. Further studies to define the natural history, pathogenesis, and diagnosis of the disease are suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnold W., Pfaltz C. R. Critical evaluation of the immunofluorescence microscopic test for identification of serum antibodies against human inner ear tissue. Acta Otolaryngol. 1987 May-Jun;103(5-6):373–378. [PubMed] [Google Scholar]
  2. Arnold W., Pfaltz R., Altermatt H. J. Evidence of serum antibodies against inner ear tissues in the blood of patients with certain sensorineural hearing disorders. Acta Otolaryngol. 1985 Mar-Apr;99(3-4):437–444. doi: 10.3109/00016488509108935. [DOI] [PubMed] [Google Scholar]
  3. Cruz O. L., Miniti A., Cossermelli W., Oliveira R. M. Autoimmune sensorineural hearing loss: a preliminary experimental study. Am J Otol. 1990 Sep;11(5):342–346. [PubMed] [Google Scholar]
  4. Harris J. P. Autoimmunity of the inner ear. Am J Otol. 1989 May;10(3):193–195. [PubMed] [Google Scholar]
  5. Harris J. P. Experimental autoimmune sensorineural hearing loss. Laryngoscope. 1987 Jan;97(1):63–76. doi: 10.1288/00005537-198701000-00014. [DOI] [PubMed] [Google Scholar]
  6. Harris J. P. Immunology of the inner ear: evidence of local antibody production. Ann Otol Rhinol Laryngol. 1984 Mar-Apr;93(2 Pt 1):157–162. doi: 10.1177/000348948409300211. [DOI] [PubMed] [Google Scholar]
  7. Harris J. P., Sharp P. A. Inner ear autoantibodies in patients with rapidly progressive sensorineural hearing loss. Laryngoscope. 1990 May;100(5):516–524. doi: 10.1288/00005537-199005000-00015. [DOI] [PubMed] [Google Scholar]
  8. Harris J. P., Woolf N. K., Ryan A. F. A reexamination of experimental type II collagen autoimmunity: middle and inner ear morphology and function. Ann Otol Rhinol Laryngol. 1986 Mar-Apr;95(2 Pt 1):176–180. doi: 10.1177/000348948609500214. [DOI] [PubMed] [Google Scholar]
  9. Hughes G. B., Barna B. P., Kinney S. E., Calabrese L. H., Nalepa N. J. Clinical diagnosis of immune inner-ear disease. Laryngoscope. 1988 Mar;98(3):251–253. doi: 10.1288/00005537-198803000-00001. [DOI] [PubMed] [Google Scholar]
  10. Hughes G. B., Barna B. P., Kinney S. E., Calabrese L. H., Nalepa N. L. Predictive value of laboratory tests in "autoimmune" inner ear disease: preliminary report. Laryngoscope. 1986 May;96(5):502–505. doi: 10.1288/00005537-198605000-00006. [DOI] [PubMed] [Google Scholar]
  11. Hughes G. B., Kinney S. E., Barna B. P., Calabrese L. H. Autoimmune reactivity in Ménière's disease: a preliminary report. Laryngoscope. 1983 Apr;93(4):410–417. doi: 10.1002/lary.1983.93.4.410. [DOI] [PubMed] [Google Scholar]
  12. Hughes G. B., Kinney S. E., Barna B. P., Calabrese L. H. Practical versus theoretical management of autoimmune inner ear disease. Laryngoscope. 1984 Jun;94(6):758–767. doi: 10.1288/00005537-198406000-00006. [DOI] [PubMed] [Google Scholar]
  13. Hughes G. B., Kinney S. E., Barna B. P., Tomsak R. L., Calabrese L. H. Autoimmune reactivity in Cogan's syndrome: a preliminary report. Otolaryngol Head Neck Surg. 1983 Feb;91(1):24–32. doi: 10.1177/019459988309100106. [DOI] [PubMed] [Google Scholar]
  14. Hughes G. B., Kinney S. E., Hamid M. A., Barna B. P., Calabrese L. H. Autoimmune vestibular dysfunction: preliminary report. Laryngoscope. 1985 Aug;95(8):893–897. doi: 10.1288/00005537-198508000-00001. [DOI] [PubMed] [Google Scholar]
  15. Ishibe T., Choe I. S., Yoo T. J. Type II collagen distribution in the ear of the developing chick embryo. Laryngoscope. 1989 May;99(5):547–553. doi: 10.1288/00005537-198905000-00015. [DOI] [PubMed] [Google Scholar]
  16. Ishibe T., Cremer M. A., Yoo T. J. Type II collagen distribution in the ear of the guinea pig fetus. Ann Otol Rhinol Laryngol. 1989 Aug;98(8 Pt 1):648–654. doi: 10.1177/000348948909800816. [DOI] [PubMed] [Google Scholar]
  17. Kanzaki J., Ouchi T. Steroid-responsive bilateral sensorineural hearing loss and immune complexes. Arch Otorhinolaryngol. 1981;230(1):5–9. doi: 10.1007/BF00665374. [DOI] [PubMed] [Google Scholar]
  18. Luetje C. M. Theoretical and practical implications for plasmapheresis in autoimmune inner ear disease. Laryngoscope. 1989 Nov;99(11):1137–1146. doi: 10.1288/00005537-198911000-00006. [DOI] [PubMed] [Google Scholar]
  19. McCabe B. F. Autoimmune inner ear disease: therapy. Am J Otol. 1989 May;10(3):196–197. [PubMed] [Google Scholar]
  20. McCabe B. F. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1979 Sep-Oct;88(5 Pt 1):585–589. doi: 10.1177/000348947908800501. [DOI] [PubMed] [Google Scholar]
  21. McCabe B. F., McCormick K. J. Tests for autoimmune disease in otology. Am J Otol. 1984 Oct;5(6):447–449. [PubMed] [Google Scholar]
  22. Rask-Andersen H., Stahle J. Immunodefence of the inner ear? Lymphocyte-macrophage interaction in the endolymphatic sac. Acta Otolaryngol. 1980 Mar-Apr;89(3-4):283–294. doi: 10.3109/00016488009127140. [DOI] [PubMed] [Google Scholar]
  23. Soliman A. M. Experimental autoimmune inner ear disease. Laryngoscope. 1989 Feb;99(2):188–193. doi: 10.1288/00005537-198902000-00011. [DOI] [PubMed] [Google Scholar]
  24. Soliman A. M. The use of immunofluorescence in the non-decalcified frozen guinea pig cochlea to detect autoantibodies in inner ear disorders. Arch Otorhinolaryngol. 1987;244(4):241–245. doi: 10.1007/BF00455313. [DOI] [PubMed] [Google Scholar]
  25. Summers R. W., Harker L. Ulcerative colitis and sensorineural hearing loss: is there a relationship? J Clin Gastroenterol. 1982 Jun;4(3):251–252. doi: 10.1097/00004836-198206000-00009. [DOI] [PubMed] [Google Scholar]
  26. Tomiyama S., Harris J. P. The endolymphatic sac: its importance in inner ear immune responses. Laryngoscope. 1986 Jun;96(6):685–691. doi: 10.1288/00005537-198606000-00018. [DOI] [PubMed] [Google Scholar]
  27. Tomiyama S., Harris J. P. The role of the endolymphatic sac in inner ear immunity. Acta Otolaryngol. 1987 Mar-Apr;103(3-4):182–188. [PubMed] [Google Scholar]
  28. Veldman J. E. Cochlear and retrocochlear immune-mediated inner ear disorders. Pathogenetic mechanisms and diagnostic tools. Ann Otol Rhinol Laryngol. 1986 Sep-Oct;95(5 Pt 1):535–540. doi: 10.1177/000348948609500518. [DOI] [PubMed] [Google Scholar]
  29. Veldman J. E. Immunology of hearing: experiments of nature. Am J Otol. 1989 May;10(3):183–187. [PubMed] [Google Scholar]
  30. Veldman J. E., Roord J. J., O'Connor A. F., Shea J. J. Autoimmunity and inner ear disorders: an immune-complex mediated sensorineural hearing loss. Laryngoscope. 1984 Apr;94(4):501–507. doi: 10.1288/00005537-198404000-00014. [DOI] [PubMed] [Google Scholar]
  31. Weber R. S., Jenkins H. A., Coker N. J. Sensorineural hearing loss associated with ulcerative colitis. A case report. Arch Otolaryngol. 1984 Dec;110(12):810–812. doi: 10.1001/archotol.1984.00800380040011. [DOI] [PubMed] [Google Scholar]
  32. Wilson W. R., Byl F. M., Laird N. The efficacy of steroids in the treatment of idiopathic sudden hearing loss. A double-blind clinical study. Arch Otolaryngol. 1980 Dec;106(12):772–776. doi: 10.1001/archotol.1980.00790360050013. [DOI] [PubMed] [Google Scholar]
  33. Yoo T. J. Etiopathogenesis of Meniere's disease: a hypothesis. Ann Otol Rhinol Laryngol Suppl. 1984 Sep-Oct;113:6–12. doi: 10.1177/00034894840930s503. [DOI] [PubMed] [Google Scholar]
  34. Yoo T. J., Floyd R. A., Sudo N., Ishibe T., Takeda T., Tomoda K., Yazawa Y., Stuart J., Choe I. S., Ha S. C. Factors influencing collagen-induced autoimmune ear disease. Am J Otolaryngol. 1985 May-Jun;6(3):209–216. doi: 10.1016/s0196-0709(85)80087-9. [DOI] [PubMed] [Google Scholar]
  35. Yoo T. J., Stuart J. M., Kang A. H., Townes A. S., Tomoda K., Dixit S. Type II collagen autoimmunity in otosclerosis and Meniere's Disease. Science. 1982 Sep 17;217(4565):1153–1155. doi: 10.1126/science.7112122. [DOI] [PubMed] [Google Scholar]
  36. Yoo T. J., Tomoda K., Hernandez A. D. Type II collagen-induced autoimmune inner ear lesions in guinea pigs. Ann Otol Rhinol Laryngol Suppl. 1984 Sep-Oct;113:3–5. doi: 10.1177/00034894840930s502. [DOI] [PubMed] [Google Scholar]
  37. Yoo T. J., Tomoda K., Stuart J. M., Cremer M. A., Townes A. S., Kang A. H. Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. Ann Otol Rhinol Laryngol. 1983 May-Jun;92(3 Pt 1):267–271. doi: 10.1177/000348948309200310. [DOI] [PubMed] [Google Scholar]
  38. Yoo T. J., Tomoda K. Type II collagen distribution in rodents. Laryngoscope. 1988 Nov;98(11):1255–1260. doi: 10.1288/00005537-198811000-00019. [DOI] [PubMed] [Google Scholar]
  39. Yoo T. J., Yazawa Y., Floyd R., Tomoda K. Antibody activity in perilymph from rats with type II collagen-induced autoimmune inner ear disease. Ann Otol Rhinol Laryngol Suppl. 1984 Sep-Oct;113:1–2. doi: 10.1177/00034894840930s501. [DOI] [PubMed] [Google Scholar]
  40. Yoo T. J., Yazawa Y., Tomoda K., Floyd R. Type II collagen-induced autoimmune endolymphatic hydrops in guinea pig. Science. 1983 Oct 7;222(4619):65–67. doi: 10.1126/science.6623056. [DOI] [PubMed] [Google Scholar]

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