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. 1991 Oct;59(10):3823–3826. doi: 10.1128/iai.59.10.3823-3826.1991

Persistent cryptosporidiosis in horses with severe combined immunodeficiency.

J M Bjorneby 1, D R Leach 1, L E Perryman 1
PMCID: PMC258958  PMID: 1894380

Abstract

Cryptosporidial infections were established in five young foals with severe combined immunodeficiency following oral administration of 10(8) Cryptosporidium parvum oocysts. All foals shed oocysts (average of 8 x 10(6) to 2 x 10(8)/g of feces) until death. Inflammation and C. parvum organisms were observed in the common bile duct, duodenum, jejunum, and ileum. Since foals with severe combined immunodeficiency lack functional T and B lymphocytes and are incapable of antigen-specific immune responses, they are well suited for evaluating the pathogenesis and treatment of persistent cryptosporidiosis.

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Selected References

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