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. 1991 Oct;59(10):3832–3835. doi: 10.1128/iai.59.10.3832-3835.1991

Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies.

H Sato 1, Y Sato 1, I Ohishi 1
PMCID: PMC258960  PMID: 1894382

Abstract

An assay of neutralizing activity against CHO cell-clustering activity, one of the most common assays for anti-pertussis toxin antibodies, did not correlate well with an assay of the protective activities of monoclonal antibodies. A better correlation between neutralization of leukocytosis-promoting or islet-activating activity and mouse protection against aerosol challenge was seen.

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Selected References

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