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. 1991 Oct;59(10):3846–3848. doi: 10.1128/iai.59.10.3846-3848.1991

Prevention of murine cerebral malaria by a stable prostacyclin analog.

K Sliwa 1, H J Grundmann 1, S Neifer 1, M F Chaves 1, G Sahlmüller 1, E Blitstein-Willinger 1, U Bienzle 1, P G Kremsner 1
PMCID: PMC258963  PMID: 1716616

Abstract

Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.

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Selected References

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