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. 1985 Nov-Dec;58(6):547–552.

Melatonin as a hormone in humans: a history.

R J Wurtman
PMCID: PMC2589962  PMID: 3914144

Abstract

This article describes the history of melatonin's transformation, in the perception of the biomedical community, from a skin-lightening agent in amphibians to a hormone in mammals, which may also exert important behavioral--and physiological--effects in humans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AXELROD J., TOMCHICK R. Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem. 1958 Sep;233(3):702–705. [PubMed] [Google Scholar]
  2. AXELROD J., WEISSBACH H. Purification and properties of hydroxyindole-O-methyl transferase. J Biol Chem. 1961 Jan;236:211–213. [PubMed] [Google Scholar]
  3. AXELROD J., WURTMAN R. J., SNYDER S. H. CONTROL OF HYDROXYINDOLE O-METHYLTRANSFERASE ACTIVITY IN THE RAT PINEAL GLAND BY ENVIRONMENTAL LIGHTING. J Biol Chem. 1965 Feb;240:949–954. [PubMed] [Google Scholar]
  4. AXELROD J., WURTMAN R. J., WINGET C. M. MELATONIN SYNTHESIS IN THE HEN PINEAL GLAND AND ITS CONTROL BY LIGHT. Nature. 1964 Mar 14;201:1134–1134. doi: 10.1038/2011134a0. [DOI] [PubMed] [Google Scholar]
  5. Adrendt J., Wetterberg L., Heyden T., Sizonenko P. C., Paunier L. Radioimmunoassay of melatonin: human serum and cerebrospinal fluid. Horm Res. 1977;8(2):65–75. doi: 10.1159/000178782. [DOI] [PubMed] [Google Scholar]
  6. Anton-Tay F., Chou C., Anton S., Wurtman R. J. Brain serotonin concentration: elevation following intraperitoneal administration of melatonin. Science. 1968 Oct 11;162(3850):277–278. doi: 10.1126/science.162.3850.277. [DOI] [PubMed] [Google Scholar]
  7. Anton-Tay F., Wurtman R. J. Regional uptake of 3H-melatonin from blood or cerebrospinal fluid by rat brain. Nature. 1969 Feb 1;221(5179):474–475. doi: 10.1038/221474a0. [DOI] [PubMed] [Google Scholar]
  8. Axelrod J., Shein H. M., Wurtman R. J. Stimulation of C14-melatonin synthesis from C14-tryptophan by noradrenaline in rat pineal in organ culture. Proc Natl Acad Sci U S A. 1969 Feb;62(2):544–549. doi: 10.1073/pnas.62.2.544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fraschini F., Mess B., Martini L. Pineal gland, melatonin and the control of luteinizing hormone secretion. Endocrinology. 1968 May;82(5):919–924. doi: 10.1210/endo-82-5-919. [DOI] [PubMed] [Google Scholar]
  10. Hirata F., Hayaishi O. Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate. J Biol Chem. 1975 Aug 10;250(15):5960–5966. [PubMed] [Google Scholar]
  11. KOPIN I. J., AXELROD J., GORDON E. The metabolic fate of H3-epinephrine and C14-metanephrine in the rat. J Biol Chem. 1961 Jul;236:2109–2113. [PubMed] [Google Scholar]
  12. Klein D. C., Weller J. L. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science. 1970 Sep 11;169(3950):1093–1095. doi: 10.1126/science.169.3950.1093. [DOI] [PubMed] [Google Scholar]
  13. Lewy A. J., Wehr T. A., Goodwin F. K., Newsome D. A., Rosenthal N. E. Manic-depressive patients may be supersensitive to light. Lancet. 1981 Feb 14;1(8216):383–384. doi: 10.1016/s0140-6736(81)91697-4. [DOI] [PubMed] [Google Scholar]
  14. Lieberman H. R., Waldhauser F., Garfield G., Lynch H. J., Wurtman R. J. Effects of melatonin on human mood and performance. Brain Res. 1984 Dec 10;323(2):201–207. doi: 10.1016/0006-8993(84)90290-7. [DOI] [PubMed] [Google Scholar]
  15. Lynch H. J., Wurtman R. J., Moskowitz M. A., Archer M. C., Ho M. H. Daily rhythm in human urinary melatonin. Science. 1975 Jan 17;187(4172):169–171. doi: 10.1126/science.1167425. [DOI] [PubMed] [Google Scholar]
  16. Moore R. Y., Traynor M. E. Diurnal rhythms in pineal N-acetyltransferase and hippocampal norepinephrine: effects of water deprivation, blinding and hypothalamic lesions. Neuroendocrinology. 1976;20(3):250–259. doi: 10.1159/000122489. [DOI] [PubMed] [Google Scholar]
  17. Ralph C. L., Mull D., Lynch H. J., Hedlund L. A melatonin rhythm persists in rat pineals in darkness. Endocrinology. 1971 Dec;89(6):1361–1366. doi: 10.1210/endo-89-6-1361. [DOI] [PubMed] [Google Scholar]
  18. Reiter R. J. Comparative physiology: pineal gland. Annu Rev Physiol. 1973;35:305–328. doi: 10.1146/annurev.ph.35.030173.001513. [DOI] [PubMed] [Google Scholar]
  19. Reiter R. J., Rollag M. D., Panke E. S., Banks A. F. Melatonin: reproductive effects. J Neural Transm Suppl. 1978;(13):209–223. [PubMed] [Google Scholar]
  20. Rosenthal N. E., Sack D. A., Gillin J. C., Lewy A. J., Goodwin F. K., Davenport Y., Mueller P. S., Newsome D. A., Wehr T. A. Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry. 1984 Jan;41(1):72–80. doi: 10.1001/archpsyc.1984.01790120076010. [DOI] [PubMed] [Google Scholar]
  21. Tamarkin L., Westrom W. K., Hamill A. I., Goldman B. D. Effect of melatonin on the reproductive systems of male and female Syrian hamsters: a diurnal rhythm in sensitivity to melatonin. Endocrinology. 1976 Dec;99(6):1534–1541. doi: 10.1210/endo-99-6-1534. [DOI] [PubMed] [Google Scholar]
  22. WURTMAN R. J., ALTSCHULE M. D., HOLMGREN U. Effects of pinealectomy and of a bovine pineal extract in rats. Am J Physiol. 1959 Jul;197(1):108–110. doi: 10.1152/ajplegacy.1959.197.1.108. [DOI] [PubMed] [Google Scholar]
  23. WURTMAN R. J., AXELROD J., CHU E. W. Melatonin, a pineal substance: effect on the rat ovary. Science. 1963 Jul 19;141(3577):277–278. doi: 10.1126/science.141.3577.277. [DOI] [PubMed] [Google Scholar]
  24. WURTMAN R. J., AXELROD J., FISCHER J. E. MELATONIN SYNTHESIS IN THE PINEAL GLAND: EFFECT OF LIGHT MEDIATED BY THE SYMPATHETIC NERVOUS SYSTEM. Science. 1964 Mar 20;143(3612):1328–1330. [PubMed] [Google Scholar]
  25. WURTMAN R. J., AXELROD J., PHILLIPS L. S. MELATONIN SYNTHESIS IN THE PINEAL GLAND: CONTROL BY LIGHT. Science. 1963 Nov 22;142(3595):1071–1073. doi: 10.1126/science.142.3595.1071. [DOI] [PubMed] [Google Scholar]
  26. WURTMAN R. J., FRANK M. M., MORSE W. H., DEWS P. B. Studies on behavior. V. Actions of l-epinephrine and related compounds. J Pharmacol Exp Ther. 1959 Dec;127:281–287. [PubMed] [Google Scholar]
  27. WURTMAN R. J., ROTH W., ALTSCHULE M. D., WURTMAN J. J. Interactions of the pineal and exposure to continuous light on organ weights of female rats. Acta Endocrinol (Copenh) 1961 Apr;36:617–624. doi: 10.1530/acta.0.0360617. [DOI] [PubMed] [Google Scholar]
  28. Waldhauser F., Weiszenbacher G., Frisch H., Zeitlhuber U., Waldhauser M., Wurtman R. J. Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet. 1984 Feb 18;1(8373):362–365. doi: 10.1016/s0140-6736(84)90412-4. [DOI] [PubMed] [Google Scholar]
  29. Wurtman R. J., Shein H. M., Larin F. Mediation by -adrenergic receptors of effect of norepinephrine on pineal synthesis of ( 14 C)serotonin and ( 14 C)melatonin. J Neurochem. 1971 Sep;18(9):1683–1687. doi: 10.1111/j.1471-4159.1971.tb03741.x. [DOI] [PubMed] [Google Scholar]

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