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. 1983 Sep-Dec;56(5-6):605–612.

H2 gene control and biological activities of a T-cell mitogen derived from Mycoplasma arthritidis: a review.

B C Cole
PMCID: PMC2590579  PMID: 6433573

Abstract

Mycoplasma arthritidis generates a soluble, non-dialysable, polyclonal mitogen which is active for murine and human T lymphocytes in the presence of an adherent, radio-resistant, Ia-bearing accessory cell population. Genetic analysis has established that the I-E sub-region of the murine H2 gene complex controls responses to the mitogen and that this control is exercised at the level of the Ia-bearing accessory cell. Lymphocyte proliferation, induction of cytotoxic lymphocytes, and interferon induction are all under Ir gene control and appear to be dependent upon binding of the mitogen to a specific Ia antigen present on a subset of splenic cells. This mycoplasma mitogen provides a new model system to define the mechanisms of Ir gene control of lymphocyte activation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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