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. 1991 Dec;59(12):4677–4680. doi: 10.1128/iai.59.12.4677-4680.1991

Effects of macrophage colony-stimulating factor on reduction of viable bacteria and survival of mice during Listeria monocytogenes infection: characteristics of monocyte subpopulations.

S Kayashima 1, S Tsuru 1, N Shinomiya 1, Y Katsura 1, K Motoyoshi 1, M Rokutanda 1, N Nagata 1
PMCID: PMC259096  PMID: 1937827

Abstract

Mice could well tolerate infection with a lethal dose of Listeria monocytogenes after intraperitoneal preinjections with 250 micrograms of macrophage colony-stimulating factor (M-CSF) per kg of body weight for 5 days. The characteristic changes in the surface markers (Mac-1, LFA-1, and F4/80) of peripheral monocytes were also investigated in order to analyze the mechanism of protection by M-CSF. This investigation shows the excellent effect of intraperitoneal preinjections of M-CSF on the reduction of viable Listeria organisms and the improvement of survival after an intravenous Listeria infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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