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. 1991 Dec;59(12):4701–4705. doi: 10.1128/iai.59.12.4701-4705.1991

Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease.

H Moll 1, C Müller 1, R Gillitzer 1, H Fuchs 1, M Röllinghoff 1, M M Simon 1, M D Kramer 1
PMCID: PMC259102  PMID: 1937831

Abstract

The expression of T-cell-associated serine proteinase 1 (MTSP-1) in vivo during Leishmania major infection was analyzed in genetically resistant C57BL/6 mice and in genetically susceptible BALB/c mice. Using a monoclonal antibody as well as an RNA probe specific for MTSP-1 to stain tissue sections, we found T cells expressing MTSP-1 in skin lesions and spleens of mice of both strains. In skin lesions, MTSP-1-positive T cells could be detected as early as 3 days after infection. Most importantly, the frequency of T cells expressing MTSP-1 was significantly higher in susceptible BALB/c mice than in resistant C57BL/6 mice. These findings suggest that MTSP-1 is associated with disease-promoting T cells and that it may be an effector molecule involved in the pathogenesis of cutaneous leishmaniasis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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